Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | HDAC1 | Q13547 | 6/20 | 0.65 |
| ▸ | HDAC9 | Q9UKV0 | 5/20 | 0.65 |
| ▸ | HDAC3 | O15379 | 5/20 | 0.65 |
| ▸ | HDAC2 | Q92769 | 5/20 | 0.65 |
| ▸ | HDAC10 | Q969S8 | 5/20 | 0.65 |
| ▸ | HDAC4 | P56524 | 4/20 | 0.65 |
| ▸ | HDAC7 | Q8WUI4 | 4/20 | 0.65 |
| ▸ | HDAC11 | Q96DB2 | 4/20 | 0.65 |
| ▸ | HDAC8 | Q9BY41 | 4/20 | 0.65 |
| ▸ | HDAC6 | Q9UBN7 | 4/20 | 0.65 |
| ▸ | HDAC5 | Q9UQL6 | 4/20 | 0.65 |
| ▸ | SMN1; SMN2 | Q16637 | 5/20 | 0.62 |
| ▸ | RAB9A | P51151 | 4/20 | 0.62 |
| ▸ | LMNA | P02545 | 2/20 | 0.62 |
| ▸ | MAPT | P10636 | 5/20 | 0.59 |
| ▸ | ALDH1A1 | P00352 | 4/20 | 0.59 |
| ▸ | PKM | P14618 | 1/20 | 0.59 |
| ▸ | PPP1CA | P62136 | 1/20 | 0.59 |
| ▸ | L3MBTL1 | Q9Y468 | 1/20 | 0.59 |
| ▸ | MAPK1 | P28482 | 2/20 | 0.57 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL3234453 | 0.86 | HDAC3 (0.69) | HDAC1HDAC9HDAC3HDAC2HDAC10 | |
| SCHEMBL7371050 | 0.80 | HDAC1 (0.81) | HDAC1HDAC9HDAC3HDAC2HDAC10 | |
| SCHEMBL7372289 | 0.80 | HDAC1 (0.81) | HDAC1HDAC9HDAC3HDAC2HDAC10 | |
| SCHEMBL3242900 | 0.80 | HDAC1 (0.65) | HDAC1HDAC9HDAC3HDAC2HDAC10 | |
| SCHEMBL7371597 | 0.79 | HDAC1 (0.73) | HDAC1HDAC9HDAC3HDAC2HDAC10 | |
| SCHEMBL3241203 | 0.79 | HDAC1 (0.64) | HDAC1HDAC9HDAC3HDAC2HDAC10 | |
| SCHEMBL13213519 | 0.77 | HDAC1 (0.69) | HDAC1HDAC9HDAC3HDAC2HDAC10 | |
| SCHEMBL3234132 | 0.77 | HDAC3 (0.61) | HDAC1HDAC9HDAC3HDAC2HDAC10 | |
| SCHEMBL7364976 | 0.76 | HDAC1 (0.68) | HDAC1HDAC9HDAC3HDAC2HDAC10 | |
| SCHEMBL14102524 | 0.75 | MAPT (0.80) | HDAC1HDAC9HDAC3HDAC2HDAC10 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2010028193-A1 | COMPOUNDS INCLUDING PIMELIC ACID DERIVATIVES AS HDAC INHIBITORS | REPLIGEN CORPORATION (US) | 2010-03-11 | — | — | WO | claimed |