Predicted protein targets (top 4)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | PIK3CD | O00329 | 20/20 | 0.89 |
| ▸ | PIK3CA | P42336 | 20/20 | 0.89 |
| ▸ | PIK3CB | P42338 | 4/20 | 0.82 |
| ▸ | PIK3CG | P48736 | 2/20 | 0.66 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL322505 | 0.94 | PIK3CD (1.00) | PIK3CDPIK3CAPIK3CBPIK3CG | |
| SCHEMBL323155 | 0.92 | PIK3CD (0.74) | PIK3CDPIK3CAPIK3CB | |
| SCHEMBL322463 | 0.90 | PIK3CD (1.00) | PIK3CDPIK3CAPIK3CBPIK3CG | |
| SCHEMBL322464 | 0.90 | PIK3CD (1.00) | PIK3CDPIK3CAPIK3CBPIK3CG | |
| Trifluoroacetic Acid SCHEMBL321678 | 0.90 | PIK3CD (0.70) | PIK3CDPIK3CAPIK3CB | |
| SCHEMBL322446 | 0.89 | PIK3CD (0.81) | PIK3CDPIK3CAPIK3CB | |
| SCHEMBL322445 | 0.89 | PIK3CD (0.81) | PIK3CDPIK3CAPIK3CB | |
| Trifluoroacetic Acid SCHEMBL323117 | 0.86 | PIK3CD (0.76) | PIK3CDPIK3CAPIK3CB | |
| SCHEMBL440081 | 0.84 | PIK3CD (1.00) | PIK3CDPIK3CAPIK3CB | |
| SCHEMBL404350 | 0.84 | PIK3CD (1.00) | PIK3CDPIK3CAPIK3CB |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 4 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-2790705-A1 | USE OF INHIBITORS OF THE ACTIVITY OR FUNCTION OF PI3K | Novartis AG (CH) | 2014-10-22 | — | — | EP | disclosed |
| WO-2013088404-A1 | Use of inhibitors of the activity or function of PI3K | NOVARTIS AG (CH) | 2013-06-20 | — | — | WO | disclosed |
| EP-2590974-A1 | TETRAHYDRO-PYRIDO-PYRIMIDINE DERIVATIVES | Novartis AG (CH) | 2013-05-15 | — | — | EP | disclosed |
| WO-2012004299-A1 | TETRAHYDRO-PYRIDO-PYRIMIDINE DERIVATIVES | NOVARTIS AG (CH) | 2012-01-12 | — | — | WO | disclosed |