Predicted protein targets (top 7)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | JAK3 | P52333 | 16/20 | 0.54 |
| ▸ | JAK2 | O60674 | 12/20 | 0.47 |
| ▸ | JAK1 | P23458 | 12/20 | 0.47 |
| ▸ | TYK2 | P29597 | 12/20 | 0.47 |
| ▸ | KIT | P10721 | 2/20 | 0.46 |
| ▸ | LCK | P06239 | 1/20 | 0.45 |
| ▸ | AKT1 | P31749 | 2/20 | 0.45 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL10232160 | 0.89 | JAK3 (0.54) | JAK3JAK2JAK1TYK2KIT | |
| SCHEMBL15988537 | 0.87 | JAK3 (0.58) | JAK3JAK2JAK1TYK2KIT | |
| SCHEMBL324657 | 0.86 | JAK3 (0.58) | JAK3JAK2JAK1TYK2KIT | |
| SCHEMBL1048374 | 0.85 | JAK3 (0.54) | JAK3JAK2LCK | |
| SCHEMBL327521 | 0.80 | JAK3 (0.71) | JAK3JAK2JAK1TYK2LCK | |
| SCHEMBL10231884 | 0.79 | JAK3 (0.69) | JAK3JAK2KITLCKAKT1 | |
| SCHEMBL323644 | 0.76 | KIT (0.60) | JAK3KITLCKAKT1 | |
| SCHEMBL322527 | 0.76 | JAK3 (0.73) | JAK3JAK2LCK | |
| SCHEMBL322963 | 0.75 | JAK3 (0.89) | JAK3JAK2JAK1TYK2LCK | |
| SCHEMBL326648 | 0.75 | JAK3 (0.57) | JAK3KITLCKAKT1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-2590981-A1 | NOVEL HOMOPIPERAZINE DERIVATIVES AS PROTEIN TYROSINE KINASE INHIBITORS AND PHARMACEUTICAL USE THEREOF | Leo Pharma A/S (DK) | 2013-05-15 | — | — | EP | disclosed |
| WO-2012003829-A1 | NOVEL HOMOPIPERAZINE DERIVATIVES AS PROTEIN TYROSINE KINASE INHIBITORS AND PHARMACEUTICAL USE THEREOF | LEO PHARMA A/S (DK) | 2012-01-12 | — | — | WO | disclosed |