Predicted protein targets (top 10)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | PIK3CG | P48736 | 20/20 | 1.00 |
| ▸ | PIK3CD | O00329 | 16/20 | 1.00 |
| ▸ | PIK3CA | P42336 | 6/20 | 0.71 |
| ▸ | PIK3CB | P42338 | 3/20 | 0.71 |
| ▸ | PAK4 | O96013 | 1/20 | 0.71 |
| ▸ | JAK1 | P23458 | 1/20 | 0.71 |
| ▸ | CSNK1A1 | P48729 | 1/20 | 0.71 |
| ▸ | AAK1 | Q2M2I8 | 1/20 | 0.71 |
| ▸ | PIP4K2C | Q8TBX8 | 1/20 | 0.71 |
| ▸ | CSNK1G1 | Q9HCP0 | 1/20 | 0.71 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL3231244 | 0.92 | PIK3CG (0.84) | PIK3CGPIK3CDPIK3CAPIK3CBPAK4 | |
| SCHEMBL3234736 | 0.86 | PIK3CG (1.00) | PIK3CGPIK3CDPIK3CAPIK3CBPAK4 | |
| SCHEMBL937638 | 0.85 | PIK3CG (0.74) | PIK3CGPIK3CDPIK3CAPIK3CBPAK4 | |
| SCHEMBL3222900 | 0.84 | PIK3CG (1.00) | PIK3CGPIK3CDPIK3CAPIK3CBPAK4 | |
| SCHEMBL3225926 | 0.84 | PIK3CG (1.00) | PIK3CGPIK3CDPIK3CAPIK3CBPAK4 | |
| SCHEMBL3226438 | 0.83 | PIK3CG (1.00) | PIK3CGPIK3CDPIK3CAPIK3CBPAK4 | |
| SCHEMBL3226712 | 0.83 | PIK3CG (1.00) | PIK3CGPIK3CDPIK3CAPIK3CBPAK4 | |
| SCHEMBL3262808 | 0.82 | PIK3CG (1.00) | PIK3CGPIK3CDPIK3CAPIK3CBPAK4 | |
| SCHEMBL3226533 | 0.82 | PIK3CG (1.00) | PIK3CGPIK3CDPIK3CAPIK3CBPAK4 | |
| SCHEMBL3218810 | 0.81 | PIK3CG (0.68) | PIK3CGPIK3CDPIK3CAPIK3CBPAK4 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2010007100-A1 | 7-SUBSTITUTED AMINO TRIAZOLES AS PI3K INHIBITORS | CELLZOME LTD (GB) | 2010-01-21 | — | — | WO | claimed |
| WO-2010007100-A1 | 7-SUBSTITUTED AMINO TRIAZOLES AS PI3K INHIBITORS | CELLZOME LTD (GB) | 2010-01-21 | — | — | WO | disclosed |
| WO-2010007100-A1 | 7-SUBSTITUTED AMINO TRIAZOLES AS PI3K INHIBITORS | CELLZOME LTD (GB) | 2010-01-21 | — | — | WO | disclosed |