Predicted protein targets (top 7)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | JAK3 | P52333 | 15/20 | 0.45 |
| ▸ | JAK1 | P23458 | 12/20 | 0.45 |
| ▸ | JAK2 | O60674 | 12/20 | 0.45 |
| ▸ | TYK2 | P29597 | 10/20 | 0.45 |
| ▸ | ENPP1 | P22413 | 1/20 | 0.43 |
| ▸ | GBA1 | P04062 | 1/20 | 0.43 |
| ▸ | RAB9A | P51151 | 1/20 | 0.43 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL326321 | 0.92 | JAK3 (0.52) | JAK3JAK1JAK2TYK2ENPP1 | |
| SCHEMBL323667 | 0.91 | GBA1 (0.51) | JAK3JAK1JAK2TYK2ENPP1 | |
| SCHEMBL323346 | 0.77 | JAK3 (0.52) | JAK3JAK1JAK2TYK2ENPP1 | |
| SCHEMBL1047948 | 0.75 | JAK3 (0.52) | JAK3JAK1JAK2TYK2ENPP1 | |
| SCHEMBL322737 | 0.75 | JAK2 (0.47) | JAK3JAK1JAK2TYK2ENPP1 | |
| SCHEMBL15663861 | 0.74 | JAK3 (0.58) | JAK3JAK1JAK2TYK2ENPP1 | |
| SCHEMBL324549 | 0.74 | JAK3 (0.52) | JAK3JAK1JAK2TYK2ENPP1 | |
| SCHEMBL15664196 | 0.73 | KIT (0.62) | JAK3JAK1JAK2TYK2ENPP1 | |
| SCHEMBL323438 | 0.72 | JAK3 (0.56) | JAK3 | |
| SCHEMBL324612 | 0.71 | JAK3 (0.61) | JAK3JAK1JAK2TYK2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 4 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-2590981-A1 | NOVEL HOMOPIPERAZINE DERIVATIVES AS PROTEIN TYROSINE KINASE INHIBITORS AND PHARMACEUTICAL USE THEREOF | Leo Pharma A/S (DK) | 2013-05-15 | — | — | EP | claimed |
| WO-2012003829-A1 | NOVEL HOMOPIPERAZINE DERIVATIVES AS PROTEIN TYROSINE KINASE INHIBITORS AND PHARMACEUTICAL USE THEREOF | LEO PHARMA A/S (DK) | 2012-01-12 | — | — | WO | claimed |
| EP-2590981-A1 | NOVEL HOMOPIPERAZINE DERIVATIVES AS PROTEIN TYROSINE KINASE INHIBITORS AND PHARMACEUTICAL USE THEREOF | Leo Pharma A/S (DK) | 2013-05-15 | — | — | EP | disclosed |
| WO-2012003829-A1 | NOVEL HOMOPIPERAZINE DERIVATIVES AS PROTEIN TYROSINE KINASE INHIBITORS AND PHARMACEUTICAL USE THEREOF | LEO PHARMA A/S (DK) | 2012-01-12 | — | — | WO | disclosed |