Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | CCNB2 | O95067 | 5/20 | 0.63 |
| ▸ | CDK1 | P06493 | 5/20 | 0.63 |
| ▸ | CCNB1 | P14635 | 5/20 | 0.63 |
| ▸ | CCNB3 | Q8WWL7 | 5/20 | 0.63 |
| ▸ | SMN1; SMN2 | Q16637 | 5/20 | 0.42 |
| ▸ | LMNA | P02545 | 5/20 | 0.42 |
| ▸ | NPSR1 | Q6W5P4 | 2/20 | 0.42 |
| ▸ | S1PR2 | O95136 | 1/20 | 0.42 |
| ▸ | ALDH1A1 | P00352 | 6/20 | 0.41 |
| ▸ | HTT | P42858 | 5/20 | 0.41 |
| ▸ | KDM4E | B2RXH2 | 5/20 | 0.41 |
| ▸ | MAPT | P10636 | 3/20 | 0.41 |
| ▸ | HSD17B10 | Q99714 | 4/20 | 0.39 |
| ▸ | TSHR | P16473 | 3/20 | 0.39 |
| ▸ | MAPK1 | P28482 | 3/20 | 0.39 |
| ▸ | TP53 | P04637 | 2/20 | 0.39 |
| ▸ | HPGD | P15428 | 2/20 | 0.37 |
| ▸ | NR2F2 | P24468 | 1/20 | 0.36 |
| ▸ | NPC1 | O15118 | 1/20 | 0.36 |
| ▸ | RAB9A | P51151 | 1/20 | 0.36 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL2808798 | 0.82 | CCNB2 (0.56) | CCNB2CDK1CCNB1CCNB3SMN1; SMN2 | |
| SCHEMBL11829828 | 0.81 | CCNB2 (0.55) | CCNB2CDK1CCNB1CCNB3SMN1; SMN2 | |
| SCHEMBL11830093 | 0.81 | CCNB2 (0.55) | CCNB2CDK1CCNB1CCNB3SMN1; SMN2 | |
| SCHEMBL11834544 | 0.81 | CCNB2 (0.55) | CCNB2CDK1CCNB1CCNB3SMN1; SMN2 | |
| SCHEMBL11841747 | 0.78 | CCNB2 (0.51) | CCNB2CDK1CCNB1CCNB3SMN1; SMN2 | |
| SCHEMBL3234796 | 0.77 | CCNB2 (1.00) | CCNB2CDK1CCNB1CCNB3SMN1; SMN2 | |
| SCHEMBL3239170 | 0.76 | CDK1 (0.63) | CCNB2CDK1CCNB1CCNB3LMNA | |
| SCHEMBL3238350 | 0.75 | CDK1 (0.64) | CCNB2CDK1CCNB1CCNB3SMN1; SMN2 | |
| SCHEMBL3241707 | 0.74 | CCNB2 (0.65) | CCNB2CDK1CCNB1CCNB3KDM4E | |
| SCHEMBL3239140 | 0.73 | CCNB2 (0.68) | CCNB2CDK1CCNB1CCNB3SMN1; SMN2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 4 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1475094-B1 | Pyrazolo[4,3-D]pyrimidines, process for their preparation and methods of use | USTAV EX BOTAN AKADEMIE VED CE (CZ) | 2010-07-28 | — | — | EP | disclosed |
| US-20070167466-A1 | \"Pyrazolo [4,3-d]pyrimidines, processes for their preparation and methods of use\ | UNIVERZITA PALACKEHO V OLOMOUCI (CZ) | 2007-07-19 | — | — | US | disclosed |
| WO-2004098608-A1 | PYRAZOLO [4, 3-D]PYRIMIDINES, PROCESSES FOR THEIR PREPARATION AND METHODS OF USE | ÚSTAV EXPERIMENTALNI BOTANIKY AKADEMIE VED CESKE REPUBLIKY (CZ) | 2004-11-18 | — | — | WO | disclosed |
| EP-1475094-A1 | Pyrazolo[4,3-D]pyrimidines, process for their preparation and methods of use | Ustav Experimentalni Botaniky Akademie ved Ceské Republiky (CZ) | 2004-11-10 | — | — | EP | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20070167466-A1 | \"Pyrazolo [4,3-d]pyrimidines, processes for their preparation and methods of use\ | CBR3, PYM1, PNPO | CCNB2 1222/4885CDK1 1025/4885CCNB1 731/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.