Predicted protein targets (top 6)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | CHRM1 | P11229 | 6/20 | 0.62 |
| ▸ | SERPINE1 | P05121 | 4/20 | 0.48 |
| ▸ | LMNA | P02545 | 1/20 | 0.46 |
| ▸ | RORC | P51449 | 1/20 | 0.44 |
| ▸ | MAPT | P10636 | 1/20 | 0.43 |
| ▸ | FEN1 | P39748 | 1/20 | 0.43 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL3236692 | 0.90 | CHRM1 (0.71) | CHRM1SERPINE1LMNA | |
| SCHEMBL3233555 | 0.89 | CHRM1 (0.64) | CHRM1LMNAMAPT | |
| SCHEMBL2877658 | 0.89 | CHRM1 (0.62) | CHRM1SERPINE1LMNARORCFEN1 | |
| SCHEMBL3237007 | 0.88 | CHRM1 (0.48) | CHRM1SERPINE1RORCMAPTFEN1 | |
| SCHEMBL3234283 | 0.88 | CHRM1 (0.65) | CHRM1LMNAMAPT | |
| SCHEMBL3234275 | 0.84 | CHRM1 (0.66) | CHRM1LMNAMAPT | |
| SCHEMBL3234394 | 0.83 | CHRM1 (0.86) | CHRM1LMNAMAPT | |
| SCHEMBL3234583 | 0.82 | CHRM1 (0.75) | CHRM1LMNAMAPT | |
| SCHEMBL3234264 | 0.80 | CHRM1 (0.73) | CHRM1LMNAMAPT | |
| SCHEMBL3237954 | 0.80 | CHRM1 (0.73) | CHRM1LMNAMAPT |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 9 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1963271-B1 | QUINOLONE M1 RECEPTOR POSITIVE ALLOSTERIC MODULATORS | MERCK SHARP & DOHME (US) | 2010-07-28 | — | — | EP | claimed |
| CN-101321733-A | Quinolone M1 receptor positive allosteric modulators | MERCK SHARP & DOHME (US) | 2008-12-10 | — | — | CN | claimed |
| US-8389545-B2 | Quinolone M1 receptor positive allosteric modulators | Merck, Sharp & Dohme, Corp. (US) | 2013-03-05 | — | — | US | disclosed |
| US-8389545-B2 | Quinolone M1 receptor positive allosteric modulators | Merck, Sharp & Dohme, Corp. (US) | 2013-03-05 | — | — | US | disclosed |
| US-8389545-B2 | Quinolone M1 receptor positive allosteric modulators | Merck, Sharp & Dohme, Corp. (US) | 2013-03-05 | — | — | US | disclosed |
| EP-1963271-B1 | QUINOLONE M1 RECEPTOR POSITIVE ALLOSTERIC MODULATORS | MERCK SHARP & DOHME (US) | 2010-07-28 | — | — | EP | disclosed |
| EP-1963271-B1 | QUINOLONE M1 RECEPTOR POSITIVE ALLOSTERIC MODULATORS | MERCK SHARP & DOHME (US) | 2010-07-28 | — | — | EP | disclosed |
| CN-101321733-A | Quinolone M1 receptor positive allosteric modulators | MERCK SHARP & DOHME (US) | 2008-12-10 | — | — | CN | disclosed |
| WO-2007067489-A1 | QUINOLONE M1 RECEPTOR POSITIVE ALLOSTERIC MODULATORS | MERCK & CO., INC. (US) | 2007-06-14 | — | — | WO | disclosed |