Predicted protein targets (top 8)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | SCN9A | Q15858 | 17/20 | 0.76 |
| ▸ | WEE1 | P30291 | 1/20 | 0.49 |
| ▸ | ALK | Q9UM73 | 1/20 | 0.49 |
| ▸ | MAPT | P10636 | 1/20 | 0.47 |
| ▸ | NPC1 | O15118 | 1/20 | 0.47 |
| ▸ | RAB9A | P51151 | 1/20 | 0.47 |
| ▸ | KCNH2 | Q12809 | 1/20 | 0.46 |
| ▸ | SCN5A | Q14524 | 1/20 | 0.46 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL3252741 | 0.93 | SCN9A (0.69) | SCN9AMAPTKCNH2SCN5A | |
| SCHEMBL3236527 | 0.88 | SCN9A (0.66) | SCN9AKCNH2SCN5A | |
| SCHEMBL17722083 | 0.86 | SCN9A (1.00) | SCN9ANPC1RAB9A | |
| SCHEMBL3125831 | 0.85 | SCN9A (0.65) | SCN9AKCNH2SCN5A | |
| SCHEMBL3246154 | 0.85 | SCN9A (0.65) | SCN9AKCNH2SCN5A | |
| SCHEMBL3250944 | 0.85 | SCN9A (0.73) | SCN9AKCNH2SCN5A | |
| SCHEMBL3121899 | 0.84 | SCN9A (0.64) | SCN9AMAPTKCNH2SCN5A | |
| SCHEMBL3251924 | 0.83 | SCN9A (0.61) | SCN9AKCNH2SCN5A | |
| SCHEMBL3247869 | 0.83 | SCN9A (0.66) | SCN9AKCNH2SCN5A | |
| SCHEMBL3247039 | 0.82 | SCN9A (0.62) | SCN9AKCNH2SCN5A |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2010022055-A2 | INHIBITORS OF VOLTAGE-GATED SODIUM CHANNELS | AMGEN INC. (US) | 2010-02-25 | — | — | WO | claimed |
| WO-2010022055-A2 | INHIBITORS OF VOLTAGE-GATED SODIUM CHANNELS | AMGEN INC. (US) | 2010-02-25 | — | — | WO | disclosed |