Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | HDAC1 | Q13547 | 13/20 | 0.59 |
| ▸ | HDAC3 | O15379 | 12/20 | 0.59 |
| ▸ | MEN1 | O00255 | 3/20 | 0.58 |
| ▸ | KMT2A | Q03164 | 3/20 | 0.58 |
| ▸ | MAPK1 | P28482 | 2/20 | 0.53 |
| ▸ | HDAC2 | Q92769 | 5/20 | 0.52 |
| ▸ | HDAC6 | Q9UBN7 | 4/20 | 0.52 |
| ▸ | HDAC10 | Q969S8 | 3/20 | 0.51 |
| ▸ | NPC1 | O15118 | 2/20 | 0.50 |
| ▸ | RAB9A | P51151 | 2/20 | 0.50 |
| ▸ | MAPT | P10636 | 1/20 | 0.50 |
| ▸ | HTT | P42858 | 1/20 | 0.50 |
| ▸ | HDAC4 | P56524 | 3/20 | 0.49 |
| ▸ | ERAP2 | Q6P179 | 1/20 | 0.49 |
| ▸ | LNPEP | Q9UIQ6 | 1/20 | 0.49 |
| ▸ | HDAC7 | Q8WUI4 | 2/20 | 0.49 |
| ▸ | HDAC11 | Q96DB2 | 2/20 | 0.49 |
| ▸ | HDAC8 | Q9BY41 | 2/20 | 0.49 |
| ▸ | HDAC9 | Q9UKV0 | 2/20 | 0.49 |
| ▸ | HDAC5 | Q9UQL6 | 2/20 | 0.49 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL3235057 | 0.91 | HDAC3 (0.59) | HDAC1HDAC3MEN1KMT2AMAPK1 | |
| SCHEMBL3238234 | 0.85 | HDAC1 (0.70) | HDAC1HDAC3HDAC2HDAC6HDAC10 | |
| SCHEMBL3233788 | 0.81 | HDAC1 (0.69) | HDAC1HDAC3MEN1KMT2AHDAC2 | |
| SCHEMBL25351587 | 0.79 | HDAC1 (0.56) | HDAC1MEN1KMT2AMAPK1NPC1 | |
| SCHEMBL3232140 | 0.78 | HDAC1 (0.84) | HDAC1HDAC3HDAC2HDAC6HDAC10 | |
| SCHEMBL7927022 | 0.78 | HDAC1 (0.79) | HDAC1HDAC3HDAC2HDAC6HDAC10 | |
| SCHEMBL3234137 | 0.78 | HDAC3 (0.70) | HDAC1HDAC3HDAC2HDAC6HDAC10 | |
| SCHEMBL3235344 | 0.75 | HDAC1 (0.76) | HDAC1HDAC3HDAC2HDAC6HDAC10 | |
| SCHEMBL20164199 | 0.75 | HDAC1 (0.52) | HDAC1HDAC3MAPTHTTERAP2 | |
| SCHEMBL1206765 | 0.75 | HDAC3 (0.53) | HDAC1HDAC3HDAC2MAPTHTT |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2010028193-A1 | COMPOUNDS INCLUDING PIMELIC ACID DERIVATIVES AS HDAC INHIBITORS | REPLIGEN CORPORATION (US) | 2010-03-11 | — | — | WO | claimed |
| WO-2010028193-A1 | COMPOUNDS INCLUDING PIMELIC ACID DERIVATIVES AS HDAC INHIBITORS | REPLIGEN CORPORATION (US) | 2010-03-11 | — | — | WO | disclosed |