SCHEMBL3236644

SCHEMBL3236644

Cc1ccoc1C(=O)N1CC2CCC1CNC2

nearest known ligand 0.62

Predicted protein targets (top 9)

geneUniProtsupporting neighboursconfidence
CHRNA4 P43681 17/20 0.62
CHRNB2 P17787 11/20 0.62
CHRNB4 P30926 11/20 0.62
CHRNA3 P32297 11/20 0.62
CHRNA7 P36544 5/20 0.57
HCRTR1 O43613 1/20 0.40
HCRTR2 O43614 1/20 0.40
TAS1R3 Q7RTX0 1/20 0.38
TAS1R1 Q7RTX1 1/20 0.38

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL3334837 0.90 CHRNA4 (0.72) CHRNA4CHRNB2CHRNB4CHRNA3CHRNA7
SCHEMBL3231503 0.85 CHRNA4 (0.62) CHRNA4CHRNB2CHRNB4CHRNA3CHRNA7
SCHEMBL3237930 0.79 CHRNA4 (0.44) CHRNA4CHRNB2CHRNB4CHRNA3CHRNA7
SCHEMBL3232991 0.77 CHRNA7 (0.60) CHRNA4CHRNB2CHRNB4CHRNA3CHRNA7
SCHEMBL585399 0.76 CHRNA4 (1.00) CHRNA4CHRNB2CHRNB4CHRNA3CHRNA7
SCHEMBL3239241 0.76 CHRNA4 (0.62) CHRNA4CHRNB2CHRNB4CHRNA3CHRNA7
SCHEMBL3335236 0.75 CHRNA4 (0.69) CHRNA4CHRNB2CHRNB4CHRNA3CHRNA7
SCHEMBL3335576 0.74 CHRNA4 (0.72) CHRNA4CHRNB2CHRNB4CHRNA3CHRNA7
SCHEMBL3336813 0.74 CHRNA4 (0.72) CHRNA4CHRNB2CHRNB4CHRNA3CHRNA7
SCHEMBL3240393 0.74 CHRNA4 (0.39) CHRNA4CHRNB2CHRNB4CHRNA3CHRNA7

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
WO-2010028011-A1 AMIDES OF DIAZABICYCLONONANES AND USES THEREOF TARGACEPT, INC. (US) 2010-03-11 WO disclosed