Predicted protein targets (top 6)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | JAK3 | P52333 | 19/20 | 0.59 |
| ▸ | JAK2 | O60674 | 8/20 | 0.50 |
| ▸ | JAK1 | P23458 | 5/20 | 0.50 |
| ▸ | TYK2 | P29597 | 5/20 | 0.50 |
| ▸ | LCK | P06239 | 3/20 | 0.49 |
| ▸ | AKT2 | P31751 | 1/20 | 0.48 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL323704 | 1.00 | JAK3 (0.59) | JAK3JAK2JAK1TYK2LCK | |
| SCHEMBL325201 | 1.00 | JAK3 (0.59) | JAK3JAK2JAK1TYK2LCK | |
| SCHEMBL15988537 | 0.82 | JAK3 (0.58) | JAK3JAK2JAK1TYK2LCK | |
| SCHEMBL323969 | 0.80 | JAK3 (0.66) | JAK3JAK2JAK1TYK2LCK | |
| SCHEMBL322963 | 0.80 | JAK3 (0.89) | JAK3JAK2JAK1TYK2LCK | |
| SCHEMBL323325 | 0.78 | JAK3 (0.68) | JAK3JAK2LCK | |
| SCHEMBL322527 | 0.78 | JAK3 (0.73) | JAK3JAK2LCK | |
| SCHEMBL323219 | 0.78 | JAK3 (0.62) | JAK3JAK2JAK1TYK2LCK | |
| SCHEMBL323181 | 0.78 | KIT (0.64) | JAK3JAK2JAK1TYK2LCK | |
| SCHEMBL324657 | 0.78 | JAK3 (0.58) | JAK3JAK2JAK1TYK2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 4 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-2590981-A1 | NOVEL HOMOPIPERAZINE DERIVATIVES AS PROTEIN TYROSINE KINASE INHIBITORS AND PHARMACEUTICAL USE THEREOF | Leo Pharma A/S (DK) | 2013-05-15 | — | — | EP | claimed |
| WO-2012003829-A1 | NOVEL HOMOPIPERAZINE DERIVATIVES AS PROTEIN TYROSINE KINASE INHIBITORS AND PHARMACEUTICAL USE THEREOF | LEO PHARMA A/S (DK) | 2012-01-12 | — | — | WO | claimed |
| EP-2590981-A1 | NOVEL HOMOPIPERAZINE DERIVATIVES AS PROTEIN TYROSINE KINASE INHIBITORS AND PHARMACEUTICAL USE THEREOF | Leo Pharma A/S (DK) | 2013-05-15 | — | — | EP | disclosed |
| WO-2012003829-A1 | NOVEL HOMOPIPERAZINE DERIVATIVES AS PROTEIN TYROSINE KINASE INHIBITORS AND PHARMACEUTICAL USE THEREOF | LEO PHARMA A/S (DK) | 2012-01-12 | — | — | WO | disclosed |