Predicted protein targets (top 5)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | SCN9A | Q15858 | 19/20 | 0.61 |
| ▸ | CNR1 | P21554 | 1/20 | 0.51 |
| ▸ | CNR2 | P34972 | 1/20 | 0.51 |
| ▸ | KCNH2 | Q12809 | 1/20 | 0.49 |
| ▸ | SCN5A | Q14524 | 1/20 | 0.49 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL3246288 | 0.90 | SCN9A (0.61) | SCN9ACNR1CNR2KCNH2SCN5A | |
| SCHEMBL3247034 | 0.87 | SCN9A (0.67) | SCN9AKCNH2SCN5A | |
| SCHEMBL3244522 | 0.87 | SCN9A (0.63) | SCN9AKCNH2SCN5A | |
| SCHEMBL3236316 | 0.86 | SCN9A (0.68) | SCN9AKCNH2SCN5A | |
| SCHEMBL3244864 | 0.85 | SCN9A (0.78) | SCN9AKCNH2SCN5A | |
| SCHEMBL3241895 | 0.81 | SCN9A (0.65) | SCN9AKCNH2SCN5A | |
| SCHEMBL3243841 | 0.81 | SCN9A (0.65) | SCN9AKCNH2SCN5A | |
| SCHEMBL3240813 | 0.81 | SCN9A (0.68) | SCN9AKCNH2SCN5A | |
| SCHEMBL3238916 | 0.81 | SCN9A (0.65) | SCN9AKCNH2SCN5A | |
| SCHEMBL3240405 | 0.80 | SCN9A (0.78) | SCN9AKCNH2SCN5A |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2010022055-A2 | INHIBITORS OF VOLTAGE-GATED SODIUM CHANNELS | AMGEN INC. (US) | 2010-02-25 | — | — | WO | claimed |
| WO-2010022055-A2 | INHIBITORS OF VOLTAGE-GATED SODIUM CHANNELS | AMGEN INC. (US) | 2010-02-25 | — | — | WO | disclosed |