Predicted protein targets (top 11)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | SCN9A | Q15858 | 14/20 | 0.60 |
| ▸ | KCNH2 | Q12809 | 1/20 | 0.49 |
| ▸ | SCN5A | Q14524 | 1/20 | 0.49 |
| ▸ | FYN | P06241 | 2/20 | 0.42 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.42 |
| ▸ | MAPT | P10636 | 1/20 | 0.42 |
| ▸ | HPGD | P15428 | 1/20 | 0.42 |
| ▸ | BRAF | P15056 | 1/20 | 0.42 |
| ▸ | PDPK1 | O15530 | 1/20 | 0.42 |
| ▸ | MAP3K7 | O43318 | 1/20 | 0.41 |
| ▸ | TAB1 | Q15750 | 1/20 | 0.41 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL3239384 | 0.87 | SCN9A (0.67) | SCN9AKCNH2SCN5A | |
| SCHEMBL3247208 | 0.84 | SCN9A (0.63) | SCN9AKCNH2SCN5AKDM4E | |
| SCHEMBL3246882 | 0.84 | SCN9A (0.63) | SCN9AKCNH2SCN5A | |
| SCHEMBL3242560 | 0.80 | SCN9A (0.57) | SCN9AKCNH2SCN5AMAP3K7TAB1 | |
| SCHEMBL3246884 | 0.80 | SCN9A (0.57) | SCN9AKCNH2SCN5A | |
| SCHEMBL3242053 | 0.79 | SCN9A (0.57) | SCN9AKCNH2SCN5A | |
| SCHEMBL3248518 | 0.79 | SCN9A (0.57) | SCN9AKCNH2SCN5A | |
| SCHEMBL3251492 | 0.77 | SCN9A (0.56) | SCN9AKCNH2SCN5AMAPT | |
| SCHEMBL3244794 | 0.76 | SCN9A (0.65) | SCN9AKCNH2SCN5A | |
| SCHEMBL3240604 | 0.76 | SCN9A (0.78) | SCN9AKCNH2SCN5A |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2010022055-A2 | INHIBITORS OF VOLTAGE-GATED SODIUM CHANNELS | AMGEN INC. (US) | 2010-02-25 | — | — | WO | claimed |
| WO-2010022055-A2 | INHIBITORS OF VOLTAGE-GATED SODIUM CHANNELS | AMGEN INC. (US) | 2010-02-25 | — | — | WO | disclosed |