Predicted protein targets (top 3)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | JAK3 | P52333 | 20/20 | 0.51 |
| ▸ | LCK | P06239 | 3/20 | 0.50 |
| ▸ | JAK2 | O60674 | 1/20 | 0.48 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL323438 | 0.87 | JAK3 (0.56) | JAK3LCK | |
| SCHEMBL323560 | 0.87 | JAK3 (0.61) | JAK3LCKJAK2 | |
| SCHEMBL1047948 | 0.82 | JAK3 (0.52) | JAK3LCKJAK2 | |
| SCHEMBL323136 | 0.79 | JAK3 (0.72) | JAK3LCKJAK2 | |
| SCHEMBL15064079 | 0.74 | JAK3 (0.65) | JAK3LCKJAK2 | |
| SCHEMBL12500533 | 0.73 | JAK3 (0.51) | JAK3LCKJAK2 | |
| SCHEMBL324434 | 0.72 | JAK3 (0.67) | JAK3LCKJAK2 | |
| SCHEMBL12500377 | 0.71 | JAK3 (0.50) | JAK3LCKJAK2 | |
| SCHEMBL322818 | 0.70 | JAK3 (0.67) | JAK3LCKJAK2 | |
| SCHEMBL1047611 | 0.70 | JAK3 (0.56) | JAK3LCKJAK2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 4 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-2590981-A1 | NOVEL HOMOPIPERAZINE DERIVATIVES AS PROTEIN TYROSINE KINASE INHIBITORS AND PHARMACEUTICAL USE THEREOF | Leo Pharma A/S (DK) | 2013-05-15 | — | — | EP | claimed |
| WO-2012003829-A1 | NOVEL HOMOPIPERAZINE DERIVATIVES AS PROTEIN TYROSINE KINASE INHIBITORS AND PHARMACEUTICAL USE THEREOF | LEO PHARMA A/S (DK) | 2012-01-12 | — | — | WO | claimed |
| EP-2590981-A1 | NOVEL HOMOPIPERAZINE DERIVATIVES AS PROTEIN TYROSINE KINASE INHIBITORS AND PHARMACEUTICAL USE THEREOF | Leo Pharma A/S (DK) | 2013-05-15 | — | — | EP | disclosed |
| WO-2012003829-A1 | NOVEL HOMOPIPERAZINE DERIVATIVES AS PROTEIN TYROSINE KINASE INHIBITORS AND PHARMACEUTICAL USE THEREOF | LEO PHARMA A/S (DK) | 2012-01-12 | — | — | WO | disclosed |