Predicted protein targets (top 14)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | NPSR1 | Q6W5P4 | 1/20 | 0.43 |
| ▸ | KMT2A | Q03164 | 3/20 | 0.39 |
| ▸ | MEN1 | O00255 | 2/20 | 0.39 |
| ▸ | HIF1A | Q16665 | 1/20 | 0.39 |
| ▸ | NPC1 | O15118 | 1/20 | 0.38 |
| ▸ | RAB9A | P51151 | 1/20 | 0.38 |
| ▸ | HCRTR1 | O43613 | 2/20 | 0.38 |
| ▸ | ALDH1A1 | P00352 | 2/20 | 0.38 |
| ▸ | GCG | P01275 | 2/20 | 0.37 |
| ▸ | SGMS2 | Q8NHU3 | 1/20 | 0.37 |
| ▸ | HCN1 | O60741 | 2/20 | 0.35 |
| ▸ | HCN4 | Q9Y3Q4 | 2/20 | 0.35 |
| ▸ | CYP2D6 | P10635 | 1/20 | 0.35 |
| ▸ | PRMT5 | O14744 | 1/20 | 0.35 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL3244651 | 0.88 | NPSR1 (0.41) | NPSR1KMT2AMEN1HIF1ANPC1 | |
| SCHEMBL3094147 | 0.84 | GCGR (0.49) | NPSR1KMT2AMEN1NPC1RAB9A | |
| SCHEMBL3095068 | 0.75 | GCG (0.45) | GCGCYP2D6 | |
| SCHEMBL3107118 | 0.73 | SMN1; SMN2 (0.35) | NPSR1KMT2ANPC1RAB9AGCG | |
| SCHEMBL3244452 | 0.73 | HPGD (0.43) | KMT2AMEN1NPC1RAB9AALDH1A1 | |
| SCHEMBL3102067 | 0.73 | KMT2A (0.39) | NPSR1KMT2AMEN1NPC1RAB9A | |
| SCHEMBL3110265 | 0.73 | GCGR (0.47) | NPSR1NPC1RAB9AALDH1A1GCG | |
| SCHEMBL3110015 | 0.72 | GCGR (0.47) | NPSR1NPC1RAB9AGCGCYP2D6 | |
| SCHEMBL3102130 | 0.71 | GCG (0.43) | GCGCYP2D6 | |
| SCHEMBL3228823 | 0.70 | GCG (0.42) | GCGCYP2D6 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-2210876-B1 | HETEROCYCLIC COMPOUND AS GLUCAGON ANTAGONIST | TAKEDA PHARMACEUTICAL (JP) | 2015-05-20 | — | — | EP | disclosed |
| EP-2210876-A1 | HETEROCYCLIC COMPOUND | Takeda Pharmaceutical Company Limited (JP) | 2010-07-28 | — | — | EP | disclosed |