Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | MAPT | P10636 | 2/20 | 0.42 |
| ▸ | TSHR | P16473 | 2/20 | 0.42 |
| ▸ | LMNA | P02545 | 1/20 | 0.42 |
| ▸ | NPSR1 | Q6W5P4 | 1/20 | 0.42 |
| ▸ | ALDH1A1 | P00352 | 2/20 | 0.40 |
| ▸ | SMN1; SMN2 | Q16637 | 4/20 | 0.40 |
| ▸ | RAB9A | P51151 | 3/20 | 0.40 |
| ▸ | MEN1 | O00255 | 1/20 | 0.40 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.40 |
| ▸ | GUCY1B2 | O75343 | 5/20 | 0.39 |
| ▸ | GUCY1A2 | P33402 | 5/20 | 0.39 |
| ▸ | GUCY1A1 | Q02108 | 5/20 | 0.39 |
| ▸ | GUCY1B1 | Q02153 | 5/20 | 0.39 |
| ▸ | TP53 | P04637 | 1/20 | 0.38 |
| ▸ | POLB | P06746 | 1/20 | 0.38 |
| ▸ | RAF1 | P04049 | 1/20 | 0.38 |
| ▸ | BRAF | P15056 | 1/20 | 0.38 |
| ▸ | NPC1 | O15118 | 1/20 | 0.38 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.38 |
| ▸ | ALOX12 | P18054 | 1/20 | 0.38 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL3263161 | 0.93 | GUCY1B2 (0.41) | SMN1; SMN2RAB9AGUCY1B2GUCY1A2GUCY1A1 | |
| SCHEMBL3236783 | 0.91 | GUCY1B2 (0.43) | SMN1; SMN2RAB9AGUCY1B2GUCY1A2GUCY1A1 | |
| SCHEMBL3236272 | 0.88 | GUCY1B2 (0.45) | SMN1; SMN2RAB9AGUCY1B2GUCY1A2GUCY1A1 | |
| SCHEMBL3231416 | 0.83 | GUCY1B2 (0.46) | GUCY1B2GUCY1A2GUCY1A1GUCY1B1 | |
| SCHEMBL3224928 | 0.83 | SMN1; SMN2 (0.40) | MAPTTSHRLMNANPSR1SMN1; SMN2 | |
| SCHEMBL3229937 | 0.82 | PTGDR2 (0.41) | SMN1; SMN2RAB9AGUCY1B2GUCY1A2GUCY1A1 | |
| SCHEMBL3233794 | 0.82 | GUCY1B2 (0.43) | LMNAALDH1A1SMN1; SMN2RAB9AMEN1 | |
| SCHEMBL3236218 | 0.82 | GUCY1B2 (0.38) | GUCY1B2GUCY1A2GUCY1A1GUCY1B1 | |
| SCHEMBL14952899 | 0.81 | GUCY1B2 (0.40) | SMN1; SMN2RAB9AGUCY1B2GUCY1A2GUCY1A1 | |
| SCHEMBL3234405 | 0.81 | NPC1 (0.43) | SMN1; SMN2RAB9AGUCY1B2GUCY1A2GUCY1A1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2010015652-A2 | THIAZOLE COMPOUNDS AS ACTIVATORS OF SOLUBLE GUANYLATE CYCLASE | SMITHKLINE BEECHAM CORPORATION (US) | 2010-02-11 | — | — | WO | disclosed |
| WO-2010015652-A2 | THIAZOLE COMPOUNDS AS ACTIVATORS OF SOLUBLE GUANYLATE CYCLASE | SMITHKLINE BEECHAM CORPORATION (US) | 2010-02-11 | — | — | WO | disclosed |