Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | POLB | P06746 | 2/20 | 0.82 |
| ▸ | HDAC1 | Q13547 | 4/20 | 0.79 |
| ▸ | HDAC2 | Q92769 | 2/20 | 0.79 |
| ▸ | HDAC8 | Q9BY41 | 2/20 | 0.79 |
| ▸ | HDAC6 | Q9UBN7 | 2/20 | 0.79 |
| ▸ | HDAC3 | O15379 | 1/20 | 0.79 |
| ▸ | HDAC4 | P56524 | 1/20 | 0.79 |
| ▸ | HDAC7 | Q8WUI4 | 1/20 | 0.79 |
| ▸ | HDAC10 | Q969S8 | 1/20 | 0.79 |
| ▸ | HDAC11 | Q96DB2 | 1/20 | 0.79 |
| ▸ | HDAC9 | Q9UKV0 | 1/20 | 0.79 |
| ▸ | HDAC5 | Q9UQL6 | 1/20 | 0.79 |
| ▸ | MAPT | P10636 | 2/20 | 0.75 |
| ▸ | CSNK1D | P48730 | 5/20 | 0.65 |
| ▸ | SMN1; SMN2 | Q16637 | 2/20 | 0.65 |
| ▸ | NFKB1 | P19838 | 1/20 | 0.65 |
| ▸ | NFKB2 | Q00653 | 1/20 | 0.65 |
| ▸ | RELA | Q04206 | 1/20 | 0.65 |
| ▸ | NPC1 | O15118 | 2/20 | 0.64 |
| ▸ | RAB9A | P51151 | 2/20 | 0.64 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL11887784 | 0.96 | POLB (0.84) | POLBHDAC1HDAC2HDAC8HDAC6 | |
| SCHEMBL8234055 | 0.89 | HDAC1 (0.79) | POLBHDAC1HDAC2HDAC8HDAC6 | |
| SCHEMBL20369717 | 0.88 | MAPT (0.77) | POLBHDAC1HDAC2HDAC8HDAC6 | |
| SCHEMBL27622427 | 0.88 | MAPT (0.77) | POLBHDAC1HDAC2HDAC8HDAC6 | |
| SCHEMBL10695859 | 0.86 | MAPT (0.75) | POLBHDAC1HDAC2HDAC8HDAC6 | |
| SCHEMBL3237781 | 0.86 | MAPT (1.00) | POLBHDAC1HDAC2HDAC8HDAC6 | |
| SCHEMBL6227275 | 0.85 | MAPT (0.73) | POLBHDAC1HDAC2HDAC8HDAC6 | |
| SCHEMBL3237055 | 0.84 | HDAC1 (0.70) | POLBHDAC1HDAC2HDAC8HDAC6 | |
| SCHEMBL5070926 | 0.83 | POLB (0.76) | POLBHDAC1HDAC2HDAC8HDAC6 | |
| SCHEMBL8234057 | 0.83 | MAPT (0.73) | POLBHDAC1HDAC2HDAC8HDAC6 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2010028193-A1 | COMPOUNDS INCLUDING PIMELIC ACID DERIVATIVES AS HDAC INHIBITORS | REPLIGEN CORPORATION (US) | 2010-03-11 | — | — | WO | disclosed |
| WO-2010028193-A1 | COMPOUNDS INCLUDING PIMELIC ACID DERIVATIVES AS HDAC INHIBITORS | REPLIGEN CORPORATION (US) | 2010-03-11 | — | — | WO | disclosed |