Predicted protein targets (top 5)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | SCN9A | Q15858 | 19/20 | 0.50 |
| ▸ | KCNH2 | Q12809 | 1/20 | 0.47 |
| ▸ | SCN5A | Q14524 | 1/20 | 0.47 |
| ▸ | CYP2D6 | P10635 | 1/20 | 0.40 |
| ▸ | CYP2C9 | P11712 | 1/20 | 0.40 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL3239595 | 1.00 | SCN9A (0.50) | SCN9AKCNH2SCN5ACYP2D6CYP2C9 | |
| SCHEMBL3239808 | 0.85 | SCN9A (0.65) | SCN9AKCNH2SCN5A | |
| SCHEMBL3241952 | 0.77 | SCN9A (0.66) | SCN9AKCNH2SCN5A | |
| SCHEMBL3248831 | 0.76 | SCN9A (0.56) | SCN9AKCNH2SCN5ACYP2D6CYP2C9 | |
| SCHEMBL3248844 | 0.76 | SCN9A (0.56) | SCN9AKCNH2SCN5ACYP2D6CYP2C9 | |
| SCHEMBL3125761 | 0.72 | SCN9A (0.84) | SCN9AKCNH2SCN5A | |
| SCHEMBL3240497 | 0.72 | SCN9A (0.85) | SCN9AKCNH2SCN5A | |
| SCHEMBL3242949 | 0.71 | SCN9A (0.73) | SCN9AKCNH2SCN5A | |
| SCHEMBL3243975 | 0.71 | SCN9A (0.73) | SCN9AKCNH2SCN5A | |
| SCHEMBL3246396 | 0.71 | SCN9A (0.70) | SCN9AKCNH2SCN5A |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2010022055-A2 | INHIBITORS OF VOLTAGE-GATED SODIUM CHANNELS | AMGEN INC. (US) | 2010-02-25 | — | — | WO | claimed |
| WO-2010022055-A2 | INHIBITORS OF VOLTAGE-GATED SODIUM CHANNELS | AMGEN INC. (US) | 2010-02-25 | — | — | WO | disclosed |