Predicted protein targets (top 18)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | NPC1 | O15118 | 1/20 | 0.57 |
| ▸ | RAB9A | P51151 | 1/20 | 0.57 |
| ▸ | LMNA | P02545 | 4/20 | 0.41 |
| ▸ | KDM4E | B2RXH2 | 7/20 | 0.40 |
| ▸ | MAPT | P10636 | 3/20 | 0.40 |
| ▸ | GFER | P55789 | 1/20 | 0.40 |
| ▸ | ALDH1A1 | P00352 | 3/20 | 0.39 |
| ▸ | POLB | P06746 | 3/20 | 0.39 |
| ▸ | CYP2D6 | P10635 | 2/20 | 0.39 |
| ▸ | CYP2C9 | P11712 | 2/20 | 0.39 |
| ▸ | CYP1A2 | P05177 | 2/20 | 0.39 |
| ▸ | CYP3A4 | P08684 | 2/20 | 0.39 |
| ▸ | CYP2C19 | P33261 | 2/20 | 0.39 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.38 |
| ▸ | MEN1 | O00255 | 3/20 | 0.37 |
| ▸ | KMT2A | Q03164 | 3/20 | 0.37 |
| ▸ | GAA | P10253 | 1/20 | 0.37 |
| ▸ | HTT | P42858 | 1/20 | 0.36 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL3126376 | 1.00 | NPC1 (0.57) | NPC1RAB9ALMNAKDM4EMAPT | |
| SCHEMBL2201892 | 0.89 | NPC1 (0.72) | NPC1RAB9ALMNAKDM4EMAPT | |
| SCHEMBL13413905 | 0.84 | NPC1 (0.78) | NPC1RAB9ALMNAKDM4EMAPT | |
| SCHEMBL3129007 | 0.84 | NPC1 (0.41) | NPC1RAB9AKDM4EMAPTGFER | |
| SCHEMBL2265774 | 0.83 | NPC1 (0.58) | NPC1RAB9ALMNAKDM4EMAPT | |
| SCHEMBL19824770 | 0.82 | NPC1 (0.65) | NPC1RAB9ALMNAKDM4EMAPT | |
| SCHEMBL27367618 | 0.81 | NPC1 (0.57) | NPC1RAB9ALMNAKDM4EMAPT | |
| SCHEMBL3557180 | 0.80 | HTR2B (0.46) | NPC1RAB9AKDM4EMAPTGFER | |
| SCHEMBL2111216 | 0.77 | NPC1 (0.58) | NPC1RAB9ALMNAKDM4EMAPT | |
| SCHEMBL2595635 | 0.77 | NPC1 (0.54) | NPC1RAB9ALMNAMAPTALDH1A1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2010022055-A2 | INHIBITORS OF VOLTAGE-GATED SODIUM CHANNELS | AMGEN INC. (US) | 2010-02-25 | — | — | WO | claimed |
| WO-2010022055-A2 | INHIBITORS OF VOLTAGE-GATED SODIUM CHANNELS | AMGEN INC. (US) | 2010-02-25 | — | — | WO | disclosed |