Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | MAPT | P10636 | 2/20 | 0.68 |
| ▸ | GLA | P06280 | 1/20 | 0.68 |
| ▸ | POLB | P06746 | 4/20 | 0.67 |
| ▸ | CYP1A1 | P04798 | 1/20 | 0.64 |
| ▸ | HDAC3 | O15379 | 2/20 | 0.58 |
| ▸ | HDAC1 | Q13547 | 2/20 | 0.58 |
| ▸ | HDAC2 | Q92769 | 2/20 | 0.58 |
| ▸ | HDAC10 | Q969S8 | 2/20 | 0.58 |
| ▸ | HDAC11 | Q96DB2 | 2/20 | 0.58 |
| ▸ | HDAC8 | Q9BY41 | 2/20 | 0.58 |
| ▸ | HDAC6 | Q9UBN7 | 2/20 | 0.58 |
| ▸ | HDAC4 | P56524 | 1/20 | 0.58 |
| ▸ | HDAC7 | Q8WUI4 | 1/20 | 0.58 |
| ▸ | HDAC9 | Q9UKV0 | 1/20 | 0.58 |
| ▸ | HDAC5 | Q9UQL6 | 1/20 | 0.58 |
| ▸ | BCHE | P06276 | 1/20 | 0.57 |
| ▸ | L3MBTL1 | Q9Y468 | 1/20 | 0.57 |
| ▸ | NCOR2 | Q9Y618 | 1/20 | 0.57 |
| ▸ | KMT2A | Q03164 | 4/20 | 0.56 |
| ▸ | TP53 | P04637 | 2/20 | 0.55 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL1107145 | 0.95 | MAPT (0.74) | MAPTGLAPOLBCYP1A1HDAC3 | |
| SCHEMBL14578751 | 0.87 | POLB (0.85) | MAPTGLAPOLBHDAC3HDAC1 | |
| SCHEMBL8737500 | 0.87 | POLB (0.84) | MAPTGLAPOLBCYP1A1HDAC3 | |
| SCHEMBL27874786 | 0.85 | KMT2A (0.77) | MAPTGLAPOLBCYP1A1HDAC3 | |
| SCHEMBL7825018 | 0.84 | POLB (0.70) | MAPTGLAPOLBCYP1A1HDAC3 | |
| SCHEMBL10469178 | 0.83 | POLB (0.90) | MAPTGLAPOLBCYP1A1BCHE | |
| SCHEMBL1064449 | 0.83 | HDAC1 (0.76) | MAPTGLAPOLBHDAC3HDAC1 | |
| SCHEMBL11170461 | 0.82 | POLB (0.77) | POLBHDAC3HDAC1HDAC2HDAC10 | |
| SCHEMBL6173694 | 0.80 | CYP1A1 (0.70) | MAPTGLAPOLBCYP1A1BCHE | |
| SCHEMBL10087214 | 0.80 | POLB (0.73) | MAPTGLAPOLBHDAC3HDAC1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2010028193-A1 | COMPOUNDS INCLUDING PIMELIC ACID DERIVATIVES AS HDAC INHIBITORS | REPLIGEN CORPORATION (US) | 2010-03-11 | — | — | WO | disclosed |
| WO-2010028193-A1 | COMPOUNDS INCLUDING PIMELIC ACID DERIVATIVES AS HDAC INHIBITORS | REPLIGEN CORPORATION (US) | 2010-03-11 | — | — | WO | disclosed |