Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | KMT2A | Q03164 | 3/20 | 0.58 |
| ▸ | MEN1 | O00255 | 2/20 | 0.58 |
| ▸ | BCHE | P06276 | 3/20 | 0.56 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.53 |
| ▸ | CYP4F2 | P78329 | 1/20 | 0.52 |
| ▸ | CYP4A11 | Q02928 | 1/20 | 0.52 |
| ▸ | SGMS2 | Q8NHU3 | 1/20 | 0.51 |
| ▸ | CASR | P41180 | 1/20 | 0.50 |
| ▸ | SPHK2 | Q9NRA0 | 1/20 | 0.49 |
| ▸ | SPHK1 | Q9NYA1 | 1/20 | 0.49 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.49 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.49 |
| ▸ | GAA | P10253 | 1/20 | 0.49 |
| ▸ | MAPT | P10636 | 1/20 | 0.49 |
| ▸ | THRB | P10828 | 1/20 | 0.49 |
| ▸ | PKM | P14618 | 1/20 | 0.49 |
| ▸ | RAB9A | P51151 | 1/20 | 0.49 |
| ▸ | BLM | P54132 | 1/20 | 0.49 |
| ▸ | L3MBTL1 | Q9Y468 | 1/20 | 0.49 |
| ▸ | NR4A2 | P43354 | 1/20 | 0.48 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL5711042 | 0.88 | CYP4F2 (0.55) | KMT2AMEN1BCHESMN1; SMN2CYP4F2 | |
| SCHEMBL323594 | 0.86 | BCHE (0.55) | KMT2AMEN1BCHEGAAMAPT | |
| SCHEMBL16463600 | 0.84 | CASR (0.70) | KMT2AMEN1CASR | |
| SCHEMBL15232861 | 0.82 | KMT2A (0.59) | KMT2AMEN1BCHESMN1; SMN2CYP4F2 | |
| SCHEMBL5319794 | 0.81 | MEN1 (0.62) | KMT2AMEN1BCHECYP4F2CYP4A11 | |
| SCHEMBL9435041 | 0.80 | KMT2A (0.84) | KMT2AMEN1BCHESMN1; SMN2SGMS2 | |
| SCHEMBL424037 | 0.80 | SMN1; SMN2 (0.61) | KMT2AMEN1SMN1; SMN2ALDH1A1GAA | |
| SCHEMBL4853220 | 0.80 | SMN1; SMN2 (0.61) | KMT2AMEN1SMN1; SMN2ALDH1A1GAA | |
| SCHEMBL1848481 | 0.80 | SMN1; SMN2 (0.61) | KMT2AMEN1SMN1; SMN2ALDH1A1GAA | |
| SCHEMBL8181061 | 0.80 | KMT2A (0.58) | KMT2AMEN1BCHESMN1; SMN2CYP4F2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-2590954-A1 | BISARYL (THIO)MORPHOLINE DERIVATIVES AS S1P MODULATORS | ABBVIE B.V. (NL) | 2013-05-15 | — | — | EP | disclosed |
| WO-2012004375-A1 | BISARYL (THIO)MORPHOLINE DERIVATIVES AS S1P MODULATORS | ABBOTT HEALTHCARE PRODUCTS B.V. (NL) | 2012-01-12 | — | — | WO | disclosed |