Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | MAPT | P10636 | 4/20 | 0.34 |
| ▸ | LMNA | P02545 | 1/20 | 0.34 |
| ▸ | TP53 | P04637 | 1/20 | 0.34 |
| ▸ | KDM4E | B2RXH2 | 7/20 | 0.34 |
| ▸ | HSD17B10 | Q99714 | 5/20 | 0.34 |
| ▸ | HPGD | P15428 | 3/20 | 0.34 |
| ▸ | ALDH1A1 | P00352 | 3/20 | 0.34 |
| ▸ | USP2 | O75604 | 2/20 | 0.34 |
| ▸ | ESR1 | P03372 | 1/20 | 0.33 |
| ▸ | RXFP1 | Q9HBX9 | 1/20 | 0.33 |
| ▸ | SLC6A2 | P23975 | 1/20 | 0.32 |
| ▸ | SLC6A4 | P31645 | 1/20 | 0.32 |
| ▸ | SLC6A3 | Q01959 | 1/20 | 0.32 |
| ▸ | KCNH2 | Q12809 | 1/20 | 0.32 |
| ▸ | CRHBP | P24387 | 1/20 | 0.32 |
| ▸ | CRHR2 | Q13324 | 1/20 | 0.32 |
| ▸ | POLB | P06746 | 4/20 | 0.32 |
| ▸ | TDP1 | Q9NUW8 | 1/20 | 0.32 |
| ▸ | MAPKAPK2 | P49137 | 1/20 | 0.32 |
| ▸ | MEN1 | O00255 | 1/20 | 0.31 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL3250546 | 0.89 | MAPT (0.36) | MAPTLMNATP53KDM4EHSD17B10 | |
| Hydrochloric Acid SCHEMBL3250854 | 0.89 | MAPT (0.36) | MAPTLMNATP53KDM4EHSD17B10 | |
| SCHEMBL3255160 | 0.89 | MAPT (0.38) | MAPTLMNATP53KDM4EHSD17B10 | |
| SCHEMBL3250883 | 0.89 | RXFP1 (0.40) | MAPTLMNAKDM4EHSD17B10HPGD | |
| Hydrochloric Acid SCHEMBL3254792 | 0.88 | MAPT (0.33) | MAPTLMNATP53KDM4EHSD17B10 | |
| Hydrochloric Acid SCHEMBL3250746 | 0.88 | MAPT (0.33) | MAPTLMNATP53KDM4EHSD17B10 | |
| SCHEMBL3251345 | 0.87 | KDM4E (0.38) | MAPTLMNATP53KDM4EHSD17B10 | |
| Hydrochloric Acid SCHEMBL3250216 | 0.87 | MAPT (0.33) | MAPTLMNATP53KDM4EHSD17B10 | |
| Hydrochloric Acid SCHEMBL3254032 | 0.87 | MAPT (0.33) | MAPTLMNATP53KDM4EHSD17B10 | |
| Hydrochloric Acid SCHEMBL3249916 | 0.87 | MAPT (0.33) | MAPTLMNATP53KDM4EHSD17B10 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1899335-B1 | PYRROLOQUINOLINE DERIVATIVES AND THEIR USE AS PROTEIN KINASE INHIBITORS | PF MEDICAMENT (FR) | 2010-05-19 | — | — | EP | claimed |