Predicted protein targets (top 14)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | KDM4E | B2RXH2 | 2/20 | 0.32 |
| ▸ | ALDH1A1 | P00352 | 2/20 | 0.32 |
| ▸ | GLA | P06280 | 1/20 | 0.32 |
| ▸ | GAA | P10253 | 1/20 | 0.32 |
| ▸ | MEN1 | O00255 | 1/20 | 0.32 |
| ▸ | KDM6B | O15054 | 1/20 | 0.32 |
| ▸ | KDM4A | O75164 | 1/20 | 0.32 |
| ▸ | MAPT | P10636 | 1/20 | 0.32 |
| ▸ | THRB | P10828 | 1/20 | 0.32 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.32 |
| ▸ | KDM4D | Q6B0I6 | 1/20 | 0.32 |
| ▸ | KDM4C | Q9H3R0 | 1/20 | 0.32 |
| ▸ | TDP1 | Q9NUW8 | 1/20 | 0.32 |
| ▸ | L3MBTL1 | Q9Y468 | 1/20 | 0.32 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL3243166 | 1.00 | KDM4E (0.32) | KDM4EALDH1A1GLAGAAMEN1 | |
| SCHEMBL1711614 | 0.91 | — | — | |
| SCHEMBL3242225 | 0.85 | — | — | |
| SCHEMBL1710373 | 0.83 | KDM4E (0.32) | KDM4EALDH1A1GLAGAAMEN1 | |
| SCHEMBL1710369 | 0.83 | KDM4E (0.32) | KDM4EALDH1A1GLAGAAMEN1 | |
| SCHEMBL3228821 | 0.83 | KDM4E (0.32) | KDM4EALDH1A1GLAGAAMEN1 | |
| SCHEMBL4443693 | 0.81 | KDM4E (0.32) | KDM4EALDH1A1GLAGAAMEN1 | |
| SCHEMBL3239889 | 0.80 | KDM4E (0.33) | KDM4EALDH1A1GLAGAAMEN1 | |
| SCHEMBL3239906 | 0.80 | KDM4E (0.33) | KDM4EALDH1A1GLAGAAMEN1 | |
| SCHEMBL12495335 | 0.78 | PIM1 (0.36) | — |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 8 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-2935270-A1 | ARYL-SUBSTITUTED FUSED BICYCLIC PYRIDAZINE COMPOUNDS | Novartis AG (CH) | 2015-10-28 | — | — | EP | disclosed |
| EP-2861585-A1 | NOVEL RING-SUBSTITUTED N-PYRIDINYL AMIDES AS KINASE INHIBITORS | Novartis AG (CH) | 2015-04-22 | — | — | EP | disclosed |
| WO-2014099880-A1 | ARYL-SUBSTITUTED FUSED BICYCLIC PYRIDAZINE COMPOUNDS | NOVARTIS AG (CH) | 2014-06-26 | — | — | WO | disclosed |
| WO-2014033630-A1 | NOVEL AMINOTHIAZOLE CARBOXAMIDES AS KINASE INHIBITORS | NOVARTIS AG (CH) | 2014-03-06 | — | — | WO | disclosed |
| EP-2681195-A1 | NOVEL KINASE INHIBITORS | Novartis AG (CH) | 2014-01-08 | — | — | EP | disclosed |
| WO-2013175388-A1 | NOVEL RING-SUBSTITUTED N-PYRIDINYL AMIDES AS KINASE INHIBITORS | NOVARTIS AG (CH) | 2013-11-28 | — | — | WO | disclosed |
| WO-2012120428-A1 | NOVEL KINASE INHIBITORS | NOVARTIS AG (CH) | 2012-09-13 | — | — | WO | disclosed |
| WO-2010026124-A1 | PICOLINAMIDE DERIVATIVES AS KINASE INHIBITORS | NOVARTIS AG (CH) | 2010-03-11 | — | — | WO | disclosed |