Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | ZAP70 | P43403 | 6/20 | 0.47 |
| ▸ | TGFBR1 | P36897 | 7/20 | 0.46 |
| ▸ | ACVR1 | Q04771 | 7/20 | 0.46 |
| ▸ | ACVR1B | P36896 | 2/20 | 0.46 |
| ▸ | ERN1 | O75460 | 1/20 | 0.45 |
| ▸ | KCNH2 | Q12809 | 2/20 | 0.45 |
| ▸ | PRKD3 | O94806 | 1/20 | 0.44 |
| ▸ | EGFR | P00533 | 1/20 | 0.44 |
| ▸ | PRKCG | P05129 | 1/20 | 0.44 |
| ▸ | PRKCB | P05771 | 1/20 | 0.44 |
| ▸ | LCK | P06239 | 1/20 | 0.44 |
| ▸ | PRKCA | P17252 | 1/20 | 0.44 |
| ▸ | PRKCH | P24723 | 1/20 | 0.44 |
| ▸ | PRKCI | P41743 | 1/20 | 0.44 |
| ▸ | PRKCE | Q02156 | 1/20 | 0.44 |
| ▸ | PRKCQ | Q04759 | 1/20 | 0.44 |
| ▸ | PRKCZ | Q05513 | 1/20 | 0.44 |
| ▸ | PRKCD | Q05655 | 1/20 | 0.44 |
| ▸ | PRKD1 | Q15139 | 1/20 | 0.44 |
| ▸ | IL2 | P60568 | 1/20 | 0.43 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL5236345 | 0.88 | ZAP70 (0.56) | ZAP70TGFBR1ACVR1ACVR1BERN1 | |
| SCHEMBL5235053 | 0.84 | ZAP70 (0.56) | ZAP70TGFBR1ACVR1ACVR1BERN1 | |
| SCHEMBL5623507 | 0.80 | ZAP70 (0.54) | ZAP70TGFBR1ACVR1ACVR1BERN1 | |
| SCHEMBL5234898 | 0.79 | ZAP70 (0.53) | ZAP70TGFBR1ACVR1ACVR1BERN1 | |
| SCHEMBL5238872 | 0.78 | ZAP70 (0.50) | ZAP70ERN1IL2MAP4K1CNR2 | |
| SCHEMBL5238770 | 0.78 | ERN1 (0.50) | ZAP70ERN1IL2MAP4K1CNR2 | |
| SCHEMBL13136625 | 0.78 | ZAP70 (0.52) | ZAP70TGFBR1ACVR1ERN1PRKD3 | |
| SCHEMBL3243299 | 0.78 | SMN1; SMN2 (0.49) | ZAP70ACVR1ERN1KCNH2 | |
| SCHEMBL5232609 | 0.77 | ZAP70 (0.55) | ZAP70TGFBR1ACVR1ACVR1BERN1 | |
| SCHEMBL5232807 | 0.76 | ERN1 (0.52) | ZAP70TGFBR1ERN1PRKD3EGFR |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2010057833-A1 | COMPOUNDS FOR TREATMENT OF DUCHENNE MUSCULAR DYSTROPHY | BIOMARIN IGA, LTD. (BS) | 2010-05-27 | — | — | WO | claimed |
| WO-2010057833-A1 | COMPOUNDS FOR TREATMENT OF DUCHENNE MUSCULAR DYSTROPHY | BIOMARIN IGA, LTD. (BS) | 2010-05-27 | — | — | WO | disclosed |
| WO-2010057833-A1 | COMPOUNDS FOR TREATMENT OF DUCHENNE MUSCULAR DYSTROPHY | BIOMARIN IGA, LTD. (BS) | 2010-05-27 | — | — | WO | disclosed |