Predicted protein targets (top 5)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | SCN9A | Q15858 | 20/20 | 0.72 |
| ▸ | SCN5A | Q14524 | 3/20 | 0.67 |
| ▸ | SCN4A | P35499 | 1/20 | 0.67 |
| ▸ | SCN3A | Q9NY46 | 1/20 | 0.67 |
| ▸ | KCNH2 | Q12809 | 2/20 | 0.57 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL3114006 | 0.93 | SCN9A (0.72) | SCN9ASCN5ASCN4ASCN3AKCNH2 | |
| SCHEMBL3242020 | 0.92 | SCN9A (0.74) | SCN9ASCN5ASCN4ASCN3AKCNH2 | |
| SCHEMBL3243380 | 0.90 | SCN9A (0.78) | SCN9ASCN5ASCN4ASCN3AKCNH2 | |
| SCHEMBL3243909 | 0.89 | SCN9A (0.74) | SCN9ASCN5ASCN4ASCN3AKCNH2 | |
| SCHEMBL3116491 | 0.89 | SCN9A (0.78) | SCN9ASCN5ASCN4ASCN3AKCNH2 | |
| SCHEMBL3251379 | 0.87 | SCN9A (0.70) | SCN9ASCN5ASCN4ASCN3AKCNH2 | |
| SCHEMBL3238300 | 0.86 | SCN9A (0.73) | SCN9ASCN5ASCN4ASCN3AKCNH2 | |
| SCHEMBL3126555 | 0.85 | SCN9A (0.74) | SCN9ASCN5ASCN4ASCN3AKCNH2 | |
| SCHEMBL3250994 | 0.85 | SCN9A (0.74) | SCN9ASCN5ASCN4ASCN3AKCNH2 | |
| SCHEMBL3126171 | 0.84 | SCN9A (0.73) | SCN9ASCN5ASCN4ASCN3AKCNH2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2010036316-A1 | UREA AND CARBAMATE COMPOUNDS AND ANALOGS AS KINASE INHIBITORS | FENG YANGBO (US) | 2010-04-01 | — | — | WO | claimed |
| WO-2010022055-A2 | INHIBITORS OF VOLTAGE-GATED SODIUM CHANNELS | AMGEN INC. (US) | 2010-02-25 | — | — | WO | claimed |
| WO-2010022055-A2 | INHIBITORS OF VOLTAGE-GATED SODIUM CHANNELS | AMGEN INC. (US) | 2010-02-25 | — | — | WO | disclosed |