SCHEMBL3244308

SCHEMBL3244308

CN1CCc2sc(CN)nc2C1

nearest known ligand 0.47

Predicted protein targets (top 20)

geneUniProtsupporting neighboursconfidence
HRH3 Q9Y5N1 5/20 0.47
CYP2C19 P33261 2/20 0.39
RAD52 P43351 3/20 0.36
RECQL P46063 1/20 0.36
PRMT5 O14744 1/20 0.35
WDR77 Q9BQA1 1/20 0.35
GRM5 P41594 1/20 0.35
KDM4E B2RXH2 6/20 0.34
ALDH1A1 P00352 6/20 0.34
HPGD P15428 3/20 0.34
GAA P10253 2/20 0.34
LMNA P02545 2/20 0.34
NPC1 O15118 1/20 0.34
RAB9A P51151 1/20 0.34
SMN1; SMN2 Q16637 1/20 0.34
KMT2A Q03164 2/20 0.33
F10 P00742 1/20 0.33
NR4A1 P22736 1/20 0.32
ADORA1 P30542 2/20 0.32
MAPT P10636 4/20 0.32

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL30620417 0.87 GRM5 (0.47) HRH3CYP2C19RAD52RECQLGRM5
SCHEMBL9574602 0.77 RAD52 (0.50) HRH3CYP2C19RAD52RECQLKDM4E
SCHEMBL8277491 0.75 HRH3 (0.48) HRH3CYP2C19RAD52PRMT5WDR77
SCHEMBL9574589 0.75 HRH3 (0.48) HRH3CYP2C19RAD52PRMT5WDR77
SCHEMBL3239830 0.75 PRMT5 (0.42) HRH3CYP2C19RAD52PRMT5WDR77
SCHEMBL19454164 0.74 HRH3 (0.47) HRH3CYP2C19RAD52PRMT5WDR77
SCHEMBL1106413 0.71 HRH3 (0.45) HRH3CYP2C19RECQLPRMT5WDR77
SCHEMBL25514692 0.71 HRH3 (0.45) HRH3CYP2C19PRMT5WDR77GRM5
SCHEMBL10312993 0.71 GRM5 (0.48) HRH3CYP2C19RAD52RECQLGRM5
SCHEMBL12017479 0.71 HRH3 (0.45) HRH3CYP2C19PRMT5WDR77GRM5

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
WO-2010001220-A1 NEW 1,2,4-TRIAZINE DERIVATIVES AND BIOLOGICAL APPLICATIONS THEREOF MUTABILIS SA (FR) 2010-01-07 WO disclosed
EP-2141164-A1 New 1,2,4-triazine derivatives and biological applications thereof Mutabilis (FR) 2010-01-06 EP disclosed