Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | AURKA | O14965 | 7/20 | 0.49 |
| ▸ | AURKB | Q96GD4 | 3/20 | 0.49 |
| ▸ | RET | P07949 | 1/20 | 0.39 |
| ▸ | JAK2 | O60674 | 4/20 | 0.38 |
| ▸ | CYP2C19 | P33261 | 4/20 | 0.38 |
| ▸ | CYP3A4 | P08684 | 3/20 | 0.38 |
| ▸ | CYP2C8 | P10632 | 3/20 | 0.38 |
| ▸ | CYP2C9 | P11712 | 3/20 | 0.38 |
| ▸ | JAK1 | P23458 | 3/20 | 0.38 |
| ▸ | TYK2 | P29597 | 3/20 | 0.38 |
| ▸ | JAK3 | P52333 | 3/20 | 0.38 |
| ▸ | ADORA3 | P0DMS8 | 2/20 | 0.38 |
| ▸ | CYP1A2 | P05177 | 2/20 | 0.38 |
| ▸ | SYK | P43405 | 2/20 | 0.37 |
| ▸ | NTRK1 | P04629 | 1/20 | 0.37 |
| ▸ | SRC | P12931 | 1/20 | 0.37 |
| ▸ | EIF2AK2 | P19525 | 1/20 | 0.37 |
| ▸ | GSK3A | P49840 | 1/20 | 0.37 |
| ▸ | GSK3B | P49841 | 1/20 | 0.37 |
| ▸ | CCNA2 | P20248 | 1/20 | 0.37 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL1298385 | 0.91 | AURKA (0.49) | AURKAAURKBRETJAK2CYP2C19 | |
| SCHEMBL1298729 | 0.90 | AURKA (0.46) | AURKAAURKBRETSYK | |
| SCHEMBL1298420 | 0.88 | AURKA (0.49) | AURKAAURKBRETJAK2CYP2C19 | |
| SCHEMBL1298726 | 0.83 | AURKA (0.50) | AURKAAURKBRETJAK2CYP2C19 | |
| SCHEMBL1298009 | 0.82 | AURKA (0.46) | AURKAAURKBRETJAK2CYP2C19 | |
| SCHEMBL1299027 | 0.81 | DHODH (0.40) | AURKAAURKBRETJAK2CYP2C19 | |
| SCHEMBL3245311 | 0.79 | JAK2 (0.43) | AURKAAURKBRETJAK2CYP2C19 | |
| SCHEMBL174382 | 0.74 | AURKA (0.71) | AURKAAURKBJAK2CYP2C19CYP3A4 | |
| SCHEMBL1299260 | 0.74 | AURKA (0.48) | AURKAAURKBRETJAK2SYK | |
| SCHEMBL173501 | 0.73 | AURKA (0.88) | AURKAAURKBJAK2CYP2C19CYP3A4 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2010002472-A1 | JAK KINASE MODULATING COMPOUNDS AND METHODS OF USE THEREOF | AMBIT BIOSCIENCES CORPORATION (US) | 2010-01-07 | — | — | WO | disclosed |