Predicted protein targets (top 10)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | SCN9A | Q15858 | 19/20 | 1.00 |
| ▸ | KCNH2 | Q12809 | 1/20 | 1.00 |
| ▸ | SCN5A | Q14524 | 1/20 | 1.00 |
| ▸ | GRIN2D | O15399 | 1/20 | 0.58 |
| ▸ | GRIN3B | O60391 | 1/20 | 0.58 |
| ▸ | GRIN1 | Q05586 | 1/20 | 0.58 |
| ▸ | GRIN2A | Q12879 | 1/20 | 0.58 |
| ▸ | GRIN2B | Q13224 | 1/20 | 0.58 |
| ▸ | GRIN2C | Q14957 | 1/20 | 0.58 |
| ▸ | GRIN3A | Q8TCU5 | 1/20 | 0.58 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL3248957 | 0.91 | SCN9A (0.84) | SCN9AKCNH2SCN5A | |
| SCHEMBL3243277 | 0.91 | SCN9A (0.82) | SCN9AKCNH2SCN5A | |
| SCHEMBL3244375 | 0.91 | SCN9A (0.82) | SCN9AKCNH2SCN5A | |
| SCHEMBL3245682 | 0.90 | SCN9A (0.81) | SCN9AKCNH2SCN5A | |
| SCHEMBL3247020 | 0.90 | SCN9A (0.81) | SCN9AKCNH2SCN5A | |
| SCHEMBL3241177 | 0.90 | SCN9A (0.81) | SCN9AKCNH2SCN5A | |
| SCHEMBL3241235 | 0.90 | SCN9A (0.81) | SCN9AKCNH2SCN5A | |
| SCHEMBL13478356 | 0.90 | SCN9A (0.81) | SCN9AKCNH2SCN5A | |
| SCHEMBL3236612 | 0.89 | SCN9A (0.79) | SCN9AKCNH2SCN5A | |
| SCHEMBL3253470 | 0.89 | SCN9A (0.79) | SCN9AKCNH2SCN5A |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2010022055-A2 | INHIBITORS OF VOLTAGE-GATED SODIUM CHANNELS | AMGEN INC. (US) | 2010-02-25 | — | — | WO | claimed |
| WO-2010022055-A2 | INHIBITORS OF VOLTAGE-GATED SODIUM CHANNELS | AMGEN INC. (US) | 2010-02-25 | — | — | WO | disclosed |