Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | MAPT | P10636 | 2/20 | 0.67 |
| ▸ | TP53 | P04637 | 2/20 | 0.67 |
| ▸ | NOTUM | Q6P988 | 2/20 | 0.56 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.56 |
| ▸ | ALDH1A1 | P00352 | 3/20 | 0.47 |
| ▸ | PPARG | P37231 | 1/20 | 0.47 |
| ▸ | NCOA2 | Q15596 | 1/20 | 0.47 |
| ▸ | NCOA1 | Q15788 | 1/20 | 0.47 |
| ▸ | NCOA3 | Q9Y6Q9 | 1/20 | 0.47 |
| ▸ | SMN1; SMN2 | Q16637 | 4/20 | 0.45 |
| ▸ | NPC1 | O15118 | 3/20 | 0.45 |
| ▸ | RAB9A | P51151 | 3/20 | 0.45 |
| ▸ | HTT | P42858 | 1/20 | 0.45 |
| ▸ | HDAC3 | O15379 | 1/20 | 0.44 |
| ▸ | HDAC4 | P56524 | 1/20 | 0.44 |
| ▸ | HDAC1 | Q13547 | 1/20 | 0.44 |
| ▸ | HDAC7 | Q8WUI4 | 1/20 | 0.44 |
| ▸ | HDAC2 | Q92769 | 1/20 | 0.44 |
| ▸ | HDAC10 | Q969S8 | 1/20 | 0.44 |
| ▸ | HDAC11 | Q96DB2 | 1/20 | 0.44 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL5621323 | 0.80 | MAPK1 (0.78) | MAPTTP53NOTUMMAPK1ALDH1A1 | |
| SCHEMBL5619922 | 0.80 | MAPT (0.68) | MAPTTP53NOTUMMAPK1ALDH1A1 | |
| SCHEMBL28393948 | 0.80 | TP53 (1.00) | MAPTTP53NOTUMMAPK1ALDH1A1 | |
| SCHEMBL5620616 | 0.77 | MAPT (0.72) | MAPTTP53NOTUMMAPK1ALDH1A1 | |
| SCHEMBL69157 | 0.76 | MAPT (0.72) | MAPTTP53NOTUMMAPK1ALDH1A1 | |
| SCHEMBL5621967 | 0.75 | NOTUM (0.67) | MAPTTP53NOTUMMAPK1ALDH1A1 | |
| SCHEMBL15498742 | 0.75 | TP53 (0.75) | MAPTTP53NOTUMMAPK1ALDH1A1 | |
| SCHEMBL19814196 | 0.74 | MAPT (0.73) | MAPTTP53NOTUMMAPK1ALDH1A1 | |
| SCHEMBL20507141 | 0.74 | HPGD (0.75) | MAPTTP53NOTUMMAPK1ALDH1A1 | |
| SCHEMBL27101311 | 0.74 | NOTUM (0.64) | MAPTTP53NOTUMMAPK1ALDH1A1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 13 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-8236838-B2 | Compounds, compositions and methods comprising isoxazole derivatives | INSTITUTE FOR ONEWORLD HEALTH (US) | 2012-08-07 | — | — | US | disclosed |
| US-8236838-B2 | Compounds, compositions and methods comprising isoxazole derivatives | INSTITUTE FOR ONEWORLD HEALTH (US) | 2012-08-07 | — | — | US | disclosed |
| US-8236838-B2 | Compounds, compositions and methods comprising isoxazole derivatives | INSTITUTE FOR ONEWORLD HEALTH (US) | 2012-08-07 | — | — | US | disclosed |
| US-20100144733-A1 | Compounds, compositions and methods comprising heteroaromatic derivatives | INSTITUTE FOR ONEWORLD HEALTH | 2010-06-10 | — | — | US | disclosed |
| US-20100144733-A1 | Compounds, compositions and methods comprising heteroaromatic derivatives | INSTITUTE FOR ONEWORLD HEALTH | 2010-06-10 | — | — | US | disclosed |
| US-20100144733-A1 | Compounds, compositions and methods comprising heteroaromatic derivatives | INSTITUTE FOR ONEWORLD HEALTH | 2010-06-10 | — | — | US | disclosed |
| US-20090318429-A1 | Compounds, Compositions and Methods Comprising Heteroaromatic Derivatives | INSTITUTE FOR ONEWORLD HEALTH | 2009-12-24 | — | — | US | disclosed |
| US-20090318429-A1 | Compounds, Compositions and Methods Comprising Heteroaromatic Derivatives | INSTITUTE FOR ONEWORLD HEALTH | 2009-12-24 | — | — | US | disclosed |
| US-20090318429-A1 | Compounds, Compositions and Methods Comprising Heteroaromatic Derivatives | INSTITUTE FOR ONEWORLD HEALTH | 2009-12-24 | — | — | US | disclosed |
| WO-2009131951-A2 | COMPOUNDS, COMPOSITIONS AND METHODS COMPRISING ISOXAZOLE DERIVATIVES | INSTITUTE FOR ONEWORLD HEALTH (US) | 2009-10-29 | — | — | WO | disclosed |
| US-20090264486-A1 | Compounds, Compositions and Methods Comprising Isoxazole Derivatives | INSTITUTE FOR ONEWORLD HEALTH | 2009-10-22 | — | — | US | disclosed |
| US-20090264486-A1 | Compounds, Compositions and Methods Comprising Isoxazole Derivatives | INSTITUTE FOR ONEWORLD HEALTH | 2009-10-22 | — | — | US | disclosed |
| US-20090264486-A1 | Compounds, Compositions and Methods Comprising Isoxazole Derivatives | INSTITUTE FOR ONEWORLD HEALTH | 2009-10-22 | — | — | US | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (3 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20090264486-A1 | Compounds, Compositions and Methods Comprising Isoxazole Derivatives | CFTR, PKD2, PKD1 | MAPT 4804/4885TP53 2431/4885NOTUM 3722/4885 |
| US-20100144733-A1 | Compounds, compositions and methods comprising heteroaromatic derivatives | CFTR, PKD1, PKD2 | MAPT 4877/4885TP53 721/4885NOTUM 3691/4885 |
| US-20090318429-A1 | Compounds, Compositions and Methods Comprising Heteroaromatic Derivatives | CFTR, PKD1, PKD2 | MAPT 4877/4885TP53 721/4885NOTUM 3691/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.