Predicted protein targets (top 4)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | MDM2 | Q00987 | 14/20 | 0.52 |
| ▸ | TP53 | P04637 | 13/20 | 0.52 |
| ▸ | PKM | P14618 | 1/20 | 0.36 |
| ▸ | ACHE | P22303 | 4/20 | 0.34 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL1321485 | 0.87 | MDM2 (0.56) | MDM2TP53PKM | |
| SCHEMBL1320307 | 0.85 | MDM2 (0.52) | MDM2TP53PKM | |
| SCHEMBL1322760 | 0.84 | MDM2 (0.56) | MDM2TP53 | |
| SCHEMBL3970399 | 0.84 | MDM2 (0.51) | MDM2TP53PKM | |
| SCHEMBL1325985 | 0.83 | MDM2 (0.55) | MDM2TP53 | |
| SCHEMBL1319084 | 0.82 | MDM2 (0.53) | MDM2TP53PKM | |
| SCHEMBL3241327 | 0.82 | MDM2 (0.53) | MDM2TP53ACHE | |
| SCHEMBL3252191 | 0.81 | MDM2 (0.53) | MDM2TP53 | |
| SCHEMBL12121928 | 0.81 | MDM2 (0.52) | MDM2TP53 | |
| SCHEMBL1322322 | 0.80 | MDM2 (0.52) | MDM2TP53PKM |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-2066318-B1 | OXINDOLE DERIVATIVES AS ANTICANCER AGENTS | HOFFMANN LA ROCHE (CH) | 2010-05-12 | — | — | EP | disclosed |