Predicted protein targets (top 6)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | MDM2 | Q00987 | 14/20 | 0.52 |
| ▸ | TP53 | P04637 | 13/20 | 0.50 |
| ▸ | PGR | P06401 | 2/20 | 0.44 |
| ▸ | MAOB | P27338 | 1/20 | 0.39 |
| ▸ | CTSB | P07858 | 1/20 | 0.37 |
| ▸ | TOP2A | P11388 | 1/20 | 0.37 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL3972727 | 0.81 | MDM2 (0.57) | MDM2TP53PGRMAOB | |
| SCHEMBL3253225 | 0.81 | MDM2 (0.53) | MDM2TP53PGRMAOB | |
| SCHEMBL3968872 | 0.79 | MDM2 (0.60) | MDM2TP53PGRMAOB | |
| SCHEMBL3246676 | 0.77 | MDM2 (0.49) | MDM2TP53PGRMAOB | |
| SCHEMBL1319883 | 0.77 | MDM2 (0.58) | MDM2TP53PGRMAOB | |
| SCHEMBL1320009 | 0.76 | MDM2 (0.57) | MDM2TP53PGRMAOB | |
| SCHEMBL1321241 | 0.75 | MDM2 (0.72) | MDM2TP53PGRMAOBCTSB | |
| SCHEMBL3969747 | 0.72 | MDM2 (0.70) | MDM2TP53PGRMAOB | |
| SCHEMBL1320412 | 0.72 | MDM2 (0.64) | MDM2TP53PGR | |
| SCHEMBL1320417 | 0.71 | MDM2 (0.71) | MDM2TP53PGRMAOB |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-2066318-B1 | OXINDOLE DERIVATIVES AS ANTICANCER AGENTS | HOFFMANN LA ROCHE (CH) | 2010-05-12 | — | — | EP | claimed |