SCHEMBL3248437

SCHEMBL3248437

Cc1cc(F)ccc1[C@H]1C[C@H](N2CCN(C)CC2)CCN1OC(=O)N(C)[C@H](C)c1cc(C(F)(F)F)cc(C(F)(F)F)c1

nearest known ligand 0.68

Predicted protein targets (top 4)

geneUniProtsupporting neighboursconfidence
TACR1 P25103 19/20 0.68
CYP3A4 P08684 2/20 0.66
SIGMAR1 Q99720 2/20 0.66
PTAFR P25105 1/20 0.59

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL3239538 0.92 TACR1 (0.78) TACR1CYP3A4SIGMAR1PTAFR
SCHEMBL3235696 0.92 TACR1 (0.78) TACR1CYP3A4SIGMAR1PTAFR
SCHEMBL3247812 0.92 TACR1 (0.68) TACR1CYP3A4SIGMAR1PTAFR
SCHEMBL3243221 0.92 TACR1 (0.68) TACR1CYP3A4SIGMAR1PTAFR
SCHEMBL3240404 0.92 TACR1 (0.67) TACR1CYP3A4SIGMAR1PTAFR
SCHEMBL3246694 0.91 TACR1 (0.67) TACR1CYP3A4SIGMAR1PTAFR
SCHEMBL3243512 0.91 TACR1 (0.67) TACR1CYP3A4SIGMAR1PTAFR
SCHEMBL6249966 0.89 TACR1 (0.63) TACR1CYP3A4SIGMAR1PTAFR
SCHEMBL4712181 0.87 TACR1 (0.80) TACR1CYP3A4SIGMAR1PTAFR
SCHEMBL4707782 0.87 TACR1 (0.80) TACR1CYP3A4SIGMAR1PTAFR

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 15 patents. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
EP-1921064-B1 Pharmaceutical composition GLAXO GROUP LTD (GB) 2010-05-19 EP claimed
EP-1524266-B1 Pharmaceutical composition GLAXO GROUP LTD (GB) 2007-02-28 EP claimed
EP-1326832-B1 CHEMICAL COMPOUNDS GLAXO GROUP LTD (GB) 2004-10-06 EP claimed
EP-2800790-B1 FREE RADICAL POLYMERIZABLE COMPOSITIONS COMPRISING IONIC SILICONES MOMENTIVE PERFORMANCE MAT INC (US) 2016-06-15 EP disclosed
EP-2800790-A2 FREE RADICAL POLYMERIZABLE COMPOSITIONS COMPRISING IONIC SILICONES Momentive Performance Materials Inc. (US) 2014-11-12 EP disclosed
US-8835583-B2 Free radical polymerizable compositions comprising ionic silicones MOMENTIVE PERFORMANCE MATERIALS INC. (US) 2014-09-16 US disclosed
WO-2013103533-A2 FREE RADICAL POLYMERIZABLE COMPOSITIONS COMPRISING IONIC SILICONES MOMENTIVE PERFORMANCE MATERIALS INC. (US) 2013-07-11 WO disclosed
US-20130172427-A1 FREE RADICAL POLYMERIZABLE COMPOSITIONS COMPRISING IONIC SILICONES MOMENTIVE PERFORMANCE MATERIALS INC. (US) 2013-07-04 US disclosed
EP-1857509-B1 UV curable coating compositions and uses thereof MOMENTIVE PERFORMANCE MAT INC (US) 2010-03-24 EP disclosed
EP-1704189-B1 UV CURABLE COATING COMPOSITIONS AND USES THEREOF GEN ELECTRIC (US) 2009-02-18 EP disclosed
EP-1857509-A1 UV curable coating compositions and uses thereof General Electric Company (US) 2007-11-21 EP disclosed
EP-1704189-A1 UV CURABLE COATING COMPOSITIONS AND USES THEREOF GENERAL ELECTRIC COMPANY (US) 2006-09-27 EP disclosed
US-6998425-B2 UV curable coating compositions and uses thereof GENERAL ELECTRIC COMPANY (US) 2006-02-14 US disclosed
WO-2005066287-A1 UV CURABLE COATING COMPOSITIONS AND USES THEREOF GENERAL ELECTRIC COMPANY (US) 2005-07-21 WO disclosed
US-20050136252-A1 UV curable coating compositions and uses thereof MOMENTIVE PERFORMANCE MATERIALS INC. 2005-06-23 US disclosed