Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | KDM4E | B2RXH2 | 10/20 | 0.38 |
| ▸ | HPGD | P15428 | 8/20 | 0.38 |
| ▸ | MAPT | P10636 | 8/20 | 0.38 |
| ▸ | ALDH1A1 | P00352 | 6/20 | 0.38 |
| ▸ | LMNA | P02545 | 4/20 | 0.38 |
| ▸ | HSD17B10 | Q99714 | 6/20 | 0.37 |
| ▸ | USP2 | O75604 | 4/20 | 0.37 |
| ▸ | POLB | P06746 | 3/20 | 0.37 |
| ▸ | TDP1 | Q9NUW8 | 1/20 | 0.37 |
| ▸ | L3MBTL1 | Q9Y468 | 1/20 | 0.37 |
| ▸ | MEN1 | O00255 | 4/20 | 0.37 |
| ▸ | KMT2A | Q03164 | 4/20 | 0.37 |
| ▸ | ADRB2 | P07550 | 1/20 | 0.37 |
| ▸ | RECQL | P46063 | 1/20 | 0.37 |
| ▸ | ESR1 | P03372 | 1/20 | 0.35 |
| ▸ | GLA | P06280 | 1/20 | 0.35 |
| ▸ | SMN1; SMN2 | Q16637 | 2/20 | 0.33 |
| ▸ | TP53 | P04637 | 2/20 | 0.33 |
| ▸ | HTT | P42858 | 2/20 | 0.33 |
| ▸ | ATM | Q13315 | 2/20 | 0.33 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL3241993 | 0.90 | KDM4E (0.38) | KDM4EHPGDMAPTALDH1A1LMNA | |
| SCHEMBL3250636 | 0.88 | KDM4E (0.38) | KDM4EHPGDMAPTALDH1A1LMNA | |
| SCHEMBL3246046 | 0.88 | KDM4E (0.46) | KDM4EHPGDMAPTALDH1A1LMNA | |
| SCHEMBL3249081 | 0.85 | KDM4E (0.40) | KDM4EHPGDMAPTALDH1A1LMNA | |
| SCHEMBL3249262 | 0.85 | KDM4E (0.43) | KDM4EHPGDMAPTALDH1A1LMNA | |
| SCHEMBL4718691 | 0.84 | KDM4E (0.38) | KDM4EHPGDMAPTALDH1A1LMNA | |
| SCHEMBL3251343 | 0.84 | KDM4E (0.35) | KDM4EHPGDMAPTALDH1A1LMNA | |
| SCHEMBL3250948 | 0.82 | KDM4E (0.46) | KDM4EHPGDMAPTALDH1A1LMNA | |
| SCHEMBL3241807 | 0.80 | KDM4E (0.48) | KDM4EHPGDMAPTALDH1A1LMNA | |
| SCHEMBL3251033 | 0.80 | KDM4E (0.43) | KDM4EHPGDMAPTALDH1A1LMNA |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1899335-B1 | PYRROLOQUINOLINE DERIVATIVES AND THEIR USE AS PROTEIN KINASE INHIBITORS | PF MEDICAMENT (FR) | 2010-05-19 | — | — | EP | claimed |
| EP-1899335-B1 | PYRROLOQUINOLINE DERIVATIVES AND THEIR USE AS PROTEIN KINASE INHIBITORS | PF MEDICAMENT (FR) | 2010-05-19 | — | — | EP | disclosed |