Predicted protein targets (top 16)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | BACE1 | P56817 | 4/20 | 0.37 |
| ▸ | KCNH2 | Q12809 | 1/20 | 0.37 |
| ▸ | ALOX15 | P16050 | 1/20 | 0.33 |
| ▸ | TSHR | P16473 | 1/20 | 0.33 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.33 |
| ▸ | HSD17B10 | Q99714 | 1/20 | 0.33 |
| ▸ | MEN1 | O00255 | 2/20 | 0.32 |
| ▸ | KMT2A | Q03164 | 2/20 | 0.32 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.32 |
| ▸ | MAPT | P10636 | 1/20 | 0.32 |
| ▸ | LOX | P28300 | 1/20 | 0.31 |
| ▸ | LOXL2 | Q9Y4K0 | 1/20 | 0.31 |
| ▸ | F2 | P00734 | 1/20 | 0.31 |
| ▸ | HCAR2 | Q8TDS4 | 1/20 | 0.30 |
| ▸ | CTSD | P07339 | 1/20 | 0.30 |
| ▸ | BACE2 | Q9Y5Z0 | 1/20 | 0.30 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL3236639 | 0.84 | BACE1 (0.35) | BACE1ALOX15TSHRMAPK1HSD17B10 | |
| SCHEMBL3243763 | 0.81 | BACE1 (0.47) | BACE1KCNH2ALOX15TSHRMAPK1 | |
| SCHEMBL3243768 | 0.76 | BACE1 (0.33) | BACE1KCNH2ALOX15TSHRMAPK1 | |
| SCHEMBL3242719 | 0.70 | BACE1 (0.46) | BACE1KCNH2CTSDBACE2 | |
| SCHEMBL3245518 | 0.69 | BACE1 (0.39) | BACE1KCNH2CTSDBACE2 | |
| SCHEMBL3240556 | 0.67 | BACE1 (0.44) | BACE1KCNH2CTSDBACE2 | |
| SCHEMBL3245127 | 0.67 | BACE1 (0.39) | BACE1KCNH2ALOX15TSHRMAPK1 | |
| SCHEMBL3243716 | 0.66 | BACE1 (0.40) | BACE1KCNH2MEN1KMT2AMAPT | |
| SCHEMBL3239135 | 0.65 | BACE1 (0.47) | BACE1KCNH2LOXLOXL2CTSD | |
| SCHEMBL3242727 | 0.65 | BACE1 (0.37) | BACE1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2010056195-A1 | NEW COMPOUNDS 575 | ASTRAZENECA AB (SE) | 2010-05-20 | — | — | WO | disclosed |