Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | KDM4E | B2RXH2 | 9/20 | 0.42 |
| ▸ | HSD17B10 | Q99714 | 8/20 | 0.42 |
| ▸ | POLB | P06746 | 6/20 | 0.42 |
| ▸ | KMT2A | Q03164 | 4/20 | 0.42 |
| ▸ | MEN1 | O00255 | 3/20 | 0.42 |
| ▸ | CYP2C9 | P11712 | 1/20 | 0.42 |
| ▸ | ADRB2 | P07550 | 1/20 | 0.41 |
| ▸ | RECQL | P46063 | 1/20 | 0.41 |
| ▸ | MAPT | P10636 | 8/20 | 0.41 |
| ▸ | RXFP1 | Q9HBX9 | 1/20 | 0.40 |
| ▸ | TDP1 | Q9NUW8 | 3/20 | 0.40 |
| ▸ | L3MBTL1 | Q9Y468 | 1/20 | 0.40 |
| ▸ | HPGD | P15428 | 7/20 | 0.39 |
| ▸ | USP2 | O75604 | 3/20 | 0.39 |
| ▸ | ESR1 | P03372 | 1/20 | 0.39 |
| ▸ | ALDH1A1 | P00352 | 6/20 | 0.39 |
| ▸ | LMNA | P02545 | 3/20 | 0.38 |
| ▸ | SMN1; SMN2 | Q16637 | 2/20 | 0.37 |
| ▸ | CRHBP | P24387 | 1/20 | 0.37 |
| ▸ | CRHR2 | Q13324 | 1/20 | 0.37 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL3244578 | 0.93 | MAPT (0.41) | KDM4EHSD17B10POLBKMT2AMEN1 | |
| SCHEMBL3248232 | 0.82 | HSD17B10 (0.47) | KDM4EHSD17B10POLBKMT2AMEN1 | |
| SCHEMBL3249025 | 0.81 | MAPT (0.52) | KDM4EHSD17B10KMT2AMEN1ADRB2 | |
| SCHEMBL3241807 | 0.80 | KDM4E (0.48) | KDM4EHSD17B10POLBKMT2AMEN1 | |
| SCHEMBL3248331 | 0.80 | KDM4E (0.60) | KDM4EHSD17B10POLBKMT2AMEN1 | |
| SCHEMBL3247632 | 0.79 | KMT2A (0.58) | KDM4EHSD17B10KMT2AMEN1ADRB2 | |
| SCHEMBL3250948 | 0.79 | KDM4E (0.46) | KDM4EHSD17B10POLBKMT2AMEN1 | |
| SCHEMBL3247255 | 0.79 | RXFP1 (0.42) | KDM4EHSD17B10POLBKMT2AMEN1 | |
| SCHEMBL3249264 | 0.78 | POLB (0.49) | KDM4EHSD17B10POLBKMT2AMEN1 | |
| SCHEMBL3254539 | 0.78 | MAPT (0.48) | KDM4EHSD17B10POLBKMT2AMEN1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1899335-B1 | PYRROLOQUINOLINE DERIVATIVES AND THEIR USE AS PROTEIN KINASE INHIBITORS | PF MEDICAMENT (FR) | 2010-05-19 | — | — | EP | claimed |
| EP-1899335-B1 | PYRROLOQUINOLINE DERIVATIVES AND THEIR USE AS PROTEIN KINASE INHIBITORS | PF MEDICAMENT (FR) | 2010-05-19 | — | — | EP | disclosed |