Predicted protein targets (top 18)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | JAK3 | P52333 | 13/20 | 0.40 |
| ▸ | JAK2 | O60674 | 11/20 | 0.40 |
| ▸ | AURKA | O14965 | 1/20 | 0.40 |
| ▸ | TTK | P33981 | 1/20 | 0.40 |
| ▸ | AURKB | Q96GD4 | 1/20 | 0.40 |
| ▸ | INCENP | Q9NQS7 | 1/20 | 0.40 |
| ▸ | NPC1 | O15118 | 1/20 | 0.38 |
| ▸ | PDPK1 | O15530 | 1/20 | 0.38 |
| ▸ | CDK5 | Q00535 | 1/20 | 0.36 |
| ▸ | CDK5R1 | Q15078 | 1/20 | 0.36 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.36 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.36 |
| ▸ | GAA | P10253 | 1/20 | 0.36 |
| ▸ | HPGD | P15428 | 1/20 | 0.36 |
| ▸ | GABRA1 | P14867 | 1/20 | 0.36 |
| ▸ | GABRB2 | P47870 | 1/20 | 0.36 |
| ▸ | MEN1 | O00255 | 1/20 | 0.36 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.36 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL13928212 | 0.97 | AURKA (0.42) | JAK3JAK2AURKATTKAURKB | |
| SCHEMBL3242013 | 0.89 | PDPK1 (0.43) | JAK3JAK2NPC1PDPK1CDK5 | |
| SCHEMBL3244692 | 0.86 | SPHK1 (0.43) | JAK3JAK2NPC1 | |
| SCHEMBL3253182 | 0.85 | JAK2 (0.43) | JAK3JAK2NPC1CDK5CDK5R1 | |
| SCHEMBL3245619 | 0.84 | AURKA (0.47) | JAK2AURKATTKAURKBINCENP | |
| Formic Acid SCHEMBL3249581 | 0.84 | JAK3 (0.36) | JAK3JAK2NPC1GABRA1GABRB2 | |
| SCHEMBL3247681 | 0.84 | JAK2 (0.42) | JAK3JAK2NPC1PDPK1GABRA1 | |
| SCHEMBL3249792 | 0.83 | NPC1 (0.40) | JAK3JAK2AURKAAURKBNPC1 | |
| Formic Acid SCHEMBL4160207 | 0.81 | AURKA (0.41) | AURKATTKAURKBINCENPPDPK1 | |
| SCHEMBL13928213 | 0.80 | JAK2 (0.38) | JAK3JAK2NPC1GABRA1GABRB2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1899335-B1 | PYRROLOQUINOLINE DERIVATIVES AND THEIR USE AS PROTEIN KINASE INHIBITORS | PF MEDICAMENT (FR) | 2010-05-19 | — | — | EP | claimed |