Predicted protein targets (top 5)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | SCN9A | Q15858 | 18/20 | 0.65 |
| ▸ | EGFR | P00533 | 1/20 | 0.45 |
| ▸ | TP53 | P04637 | 1/20 | 0.45 |
| ▸ | KCNH2 | Q12809 | 1/20 | 0.43 |
| ▸ | SCN5A | Q14524 | 1/20 | 0.43 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL3128619 | 1.00 | SCN9A (0.65) | SCN9AEGFRTP53KCNH2SCN5A | |
| SCHEMBL3128134 | 0.85 | SCN9A (0.80) | SCN9AKCNH2SCN5A | |
| SCHEMBL3247236 | 0.83 | SCN9A (0.66) | SCN9ATP53 | |
| SCHEMBL3241270 | 0.82 | SCN9A (0.71) | SCN9A | |
| SCHEMBL3233208 | 0.80 | SCN9A (0.69) | SCN9A | |
| SCHEMBL3240625 | 0.80 | SCN9A (0.69) | SCN9A | |
| SCHEMBL3243808 | 0.80 | SCN9A (0.69) | SCN9AKCNH2SCN5A | |
| SCHEMBL3126617 | 0.79 | SCN9A (0.73) | SCN9AKCNH2SCN5A | |
| SCHEMBL17722185 | 0.79 | SCN9A (1.00) | SCN9A | |
| SCHEMBL3243811 | 0.77 | SCN9A (0.69) | SCN9A |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2010022055-A2 | INHIBITORS OF VOLTAGE-GATED SODIUM CHANNELS | AMGEN INC. (US) | 2010-02-25 | — | — | WO | claimed |
| WO-2010022055-A2 | INHIBITORS OF VOLTAGE-GATED SODIUM CHANNELS | AMGEN INC. (US) | 2010-02-25 | — | — | WO | disclosed |