Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | JAK2 | O60674 | 7/20 | 0.46 |
| ▸ | JAK3 | P52333 | 4/20 | 0.46 |
| ▸ | CYP3A4 | P08684 | 3/20 | 0.46 |
| ▸ | CYP2C8 | P10632 | 3/20 | 0.46 |
| ▸ | CYP2C9 | P11712 | 3/20 | 0.46 |
| ▸ | JAK1 | P23458 | 3/20 | 0.46 |
| ▸ | TYK2 | P29597 | 3/20 | 0.46 |
| ▸ | CYP2C19 | P33261 | 3/20 | 0.46 |
| ▸ | ADORA3 | P0DMS8 | 2/20 | 0.46 |
| ▸ | CYP1A2 | P05177 | 1/20 | 0.46 |
| ▸ | AURKA | O14965 | 6/20 | 0.38 |
| ▸ | AURKB | Q96GD4 | 5/20 | 0.38 |
| ▸ | NTRK1 | P04629 | 3/20 | 0.37 |
| ▸ | LIMK1 | P53667 | 1/20 | 0.37 |
| ▸ | LIMK2 | P53671 | 1/20 | 0.37 |
| ▸ | SYK | P43405 | 2/20 | 0.37 |
| ▸ | PLK4 | O00444 | 1/20 | 0.35 |
| ▸ | PAK4 | O96013 | 1/20 | 0.35 |
| ▸ | SRC | P12931 | 1/20 | 0.35 |
| ▸ | EIF2AK2 | P19525 | 1/20 | 0.35 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL1298346 | 0.92 | JAK2 (0.42) | JAK2JAK3CYP3A4CYP2C8CYP2C9 | |
| SCHEMBL1299399 | 0.91 | JAK2 (0.41) | JAK2JAK3CYP3A4CYP2C8CYP2C9 | |
| SCHEMBL1298822 | 0.91 | JAK2 (0.41) | JAK2JAK3CYP3A4CYP2C8CYP2C9 | |
| SCHEMBL1298684 | 0.90 | RET (0.43) | JAK2JAK3CYP3A4CYP2C8CYP2C9 | |
| SCHEMBL1298566 | 0.89 | JAK2 (0.44) | JAK2JAK3CYP3A4CYP2C8CYP2C9 | |
| SCHEMBL1299087 | 0.86 | JAK2 (0.42) | JAK2JAK3CYP3A4CYP2C8CYP2C9 | |
| SCHEMBL1298695 | 0.86 | JAK2 (0.59) | JAK2JAK3CYP3A4CYP2C8CYP2C9 | |
| SCHEMBL1299333 | 0.85 | JAK2 (0.47) | JAK2JAK3CYP3A4CYP2C8CYP2C9 | |
| SCHEMBL1298975 | 0.85 | AURKA (0.44) | JAK2JAK3CYP3A4CYP2C8CYP2C9 | |
| SCHEMBL1324745 | 0.85 | JAK2 (0.44) | JAK2JAK3CYP3A4CYP2C8CYP2C9 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2010002472-A1 | JAK KINASE MODULATING COMPOUNDS AND METHODS OF USE THEREOF | AMBIT BIOSCIENCES CORPORATION (US) | 2010-01-07 | — | — | WO | claimed |
| WO-2010002472-A1 | JAK KINASE MODULATING COMPOUNDS AND METHODS OF USE THEREOF | AMBIT BIOSCIENCES CORPORATION (US) | 2010-01-07 | — | — | WO | disclosed |