SCHEMBL3249788

SCHEMBL3249788

CC1=C(C(=O)C2=C(C)C(C)(C)CCC2)CCCC1(C)C

nearest known ligand 0.41

Predicted protein targets (top 20)

geneUniProtsupporting neighboursconfidence
CYP1A2 P05177 2/20 0.41
HAO1 Q9UJM8 1/20 0.35
ALDH1A1 P00352 5/20 0.34
TDP1 Q9NUW8 1/20 0.34
GRIK1 P39086 2/20 0.33
GRIK2 Q13002 1/20 0.33
POLB P06746 1/20 0.33
FFAR3 O14843 1/20 0.32
RXRA P19793 7/20 0.32
RARA P10276 6/20 0.32
RARB P10826 6/20 0.32
RARG P13631 6/20 0.32
MAPT P10636 4/20 0.32
RXRB P28702 4/20 0.32
RXRG P48443 4/20 0.32
PTGS1 P23219 3/20 0.32
RORC P51449 2/20 0.32
CYP3A4 P08684 2/20 0.32
ADORA3 P0DMS8 2/20 0.32
MAPK1 P28482 2/20 0.32

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL9959984 0.85 CYP1A2 (0.43) CYP1A2HAO1ALDH1A1GRIK1GRIK2
SCHEMBL4464355 0.85 CYP1A2 (0.40) CYP1A2HAO1ALDH1A1TDP1GRIK1
SCHEMBL12813290 0.80 NPC1 (0.40) ALDH1A1TDP1RXRARARARARB
SCHEMBL31305881 0.79 CYP1A2 (0.36) CYP1A2HAO1ALDH1A1TDP1POLB
SCHEMBL28960507 0.77 HAO1 (0.36) CYP1A2HAO1ALDH1A1TDP1GRIK1
SCHEMBL29060322 0.77 CYP1A2 (0.41) CYP1A2HAO1ALDH1A1TDP1RXRA
SCHEMBL28707546 0.77 CYP1A2 (0.41) CYP1A2HAO1ALDH1A1TDP1RXRA
SCHEMBL11563975 0.77 CYP1A2 (0.41) CYP1A2HAO1ALDH1A1TDP1RXRA
SCHEMBL28891597 0.74 CYP1A2 (0.36) CYP1A2HAO1ALDH1A1TDP1GRIK1
SCHEMBL10946665 0.71 GRIK1 (0.34) CYP1A2HAO1GRIK1GRIK2RXRA

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 6 patents. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
US-8674143-B2 Synthesis of green ketone intermediate DSM IP ASSETS, B.V. (NL) 2014-03-18 US claimed
US-20120283476-A1 SYNTHESIS OF GREEN KETONE INTERMEDIATE DSM IP ASSETS, B.V. (NL) 2012-11-08 US claimed
WO-2010043522-A1 SYNTHESIS OF GREEN KETONE INTERMEDIATE DSM IP ASSETS B.V. (NL) 2010-04-22 WO claimed
US-8674143-B2 Synthesis of green ketone intermediate DSM IP ASSETS, B.V. (NL) 2014-03-18 US disclosed
US-20120283476-A1 SYNTHESIS OF GREEN KETONE INTERMEDIATE DSM IP ASSETS, B.V. (NL) 2012-11-08 US disclosed
WO-2010043522-A1 SYNTHESIS OF GREEN KETONE INTERMEDIATE DSM IP ASSETS B.V. (NL) 2010-04-22 WO disclosed