Predicted protein targets (top 11)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | CNR1 | P21554 | 12/20 | 0.73 |
| ▸ | CNR2 | P34972 | 5/20 | 0.49 |
| ▸ | HTR1A | P08908 | 1/20 | 0.49 |
| ▸ | TSPO | P30536 | 1/20 | 0.49 |
| ▸ | OPRM1 | P35372 | 1/20 | 0.49 |
| ▸ | OPRK1 | P41145 | 1/20 | 0.49 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.48 |
| ▸ | MEN1 | O00255 | 1/20 | 0.48 |
| ▸ | MAPT | P10636 | 1/20 | 0.48 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.48 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.48 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL3828981 | 0.90 | CNR1 (0.68) | CNR1CNR2 | |
| SCHEMBL219356 | 0.88 | CNR1 (0.67) | CNR1CNR2KDM4EMEN1MAPT | |
| SCHEMBL3827684 | 0.86 | CNR1 (0.70) | CNR1CNR2 | |
| SCHEMBL2872140 | 0.85 | CNR2 (0.64) | CNR1CNR2 | |
| SCHEMBL4662687 | 0.85 | CNR1 (0.58) | CNR1CNR2KDM4EMEN1MAPT | |
| SCHEMBL4888462 | 0.84 | CNR1 (0.71) | CNR1CNR2 | |
| SCHEMBL3252718 | 0.84 | CNR1 (0.57) | CNR1CNR2 | |
| Jhu-75528 SCHEMBL31038583 | 0.84 | CNR1 (1.00) | CNR1CNR2HTR1ATSPOOPRM1 | |
| SCHEMBL909047 | 0.83 | CNR1 (0.61) | CNR1CNR2 | |
| SCHEMBL4907403 | 0.83 | CNR1 (0.56) | CNR1CNR2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1878723-B1 | N-[(1,5-diphenyl-1H-pyrazol-3-yl)methyl]sulfonamide derivatives antagonists of the CB1 cannabinoids receptors | SANOFI AVENTIS (FR) | 2010-05-26 | — | — | EP | disclosed |
| EP-1878723-A1 | N-[(1,5-diphenyl-1H-pyrazol-3-yl)methyl]sulfonamide derivatives antagonists of the CB1 cannabinoids receptors | Sanofi-Aventis (FR) | 2008-01-16 | — | — | EP | disclosed |