Predicted protein targets (top 16)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | TDP1 | Q9NUW8 | 6/20 | 0.54 |
| ▸ | PARG | Q86W56 | 1/20 | 0.51 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.46 |
| ▸ | BRAF | P15056 | 1/20 | 0.44 |
| ▸ | MAPT | P10636 | 8/20 | 0.44 |
| ▸ | TP53 | P04637 | 7/20 | 0.44 |
| ▸ | POLB | P06746 | 6/20 | 0.44 |
| ▸ | SMN1; SMN2 | Q16637 | 3/20 | 0.44 |
| ▸ | LMNA | P02545 | 2/20 | 0.44 |
| ▸ | L3MBTL1 | Q9Y468 | 1/20 | 0.43 |
| ▸ | TAS2R14 | Q9NYV8 | 1/20 | 0.42 |
| ▸ | BACE1 | P56817 | 1/20 | 0.42 |
| ▸ | MEN1 | O00255 | 1/20 | 0.41 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.41 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.40 |
| ▸ | RECQL | P46063 | 1/20 | 0.40 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL3248538 | 1.00 | TDP1 (0.54) | TDP1PARGALDH1A1BRAFMAPT | |
| SCHEMBL3242536 | 0.99 | TDP1 (0.53) | TDP1PARGALDH1A1BRAFMAPT | |
| SCHEMBL3243012 | 0.95 | PARG (0.56) | TDP1PARGALDH1A1BRAFMAPT | |
| SCHEMBL3245470 | 0.91 | PARG (0.50) | TDP1PARGALDH1A1BRAFMAPT | |
| SCHEMBL3242768 | 0.90 | PARG (0.45) | TDP1PARGALDH1A1BRAFMAPT | |
| SCHEMBL3252622 | 0.90 | TDP1 (0.54) | TDP1PARGALDH1A1BRAFMAPT | |
| SCHEMBL3251568 | 0.89 | PARG (0.48) | TDP1PARGALDH1A1BRAFMAPT | |
| SCHEMBL3251014 | 0.89 | TDP1 (0.53) | TDP1PARGBRAFMAPTTP53 | |
| SCHEMBL3254632 | 0.88 | PARG (0.46) | TDP1PARGALDH1A1BRAFMAPT | |
| SCHEMBL3247256 | 0.86 | TDP1 (0.53) | TDP1PARGALDH1A1MAPTTP53 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 4 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1899335-B1 | PYRROLOQUINOLINE DERIVATIVES AND THEIR USE AS PROTEIN KINASE INHIBITORS | PF MEDICAMENT (FR) | 2010-05-19 | — | — | EP | claimed |
| EP-1899335-A1 | PYRROLOQUINOLINE DERIVATIVES AND THEIR USE AS PROTEIN KINASE INHIBITORS | PIERRE FABRE MEDICAMENT (FR) | 2008-03-19 | — | — | EP | claimed |
| WO-2007003611-A1 | PYRROLOQUINOLINE DERIVATIVES AND THEIR USE AS PROTEIN KINASE INHIBITORS | PIERRE FABRE MEDICAMENT (FR) | 2007-01-11 | — | — | WO | claimed |
| EP-1899335-B1 | PYRROLOQUINOLINE DERIVATIVES AND THEIR USE AS PROTEIN KINASE INHIBITORS | PF MEDICAMENT (FR) | 2010-05-19 | — | — | EP | disclosed |