Predicted protein targets (top 5)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | HCRTR1 | O43613 | 17/20 | 0.40 |
| ▸ | HCRTR2 | O43614 | 17/20 | 0.40 |
| ▸ | HRH3 | Q9Y5N1 | 1/20 | 0.38 |
| ▸ | BACE1 | P56817 | 1/20 | 0.38 |
| ▸ | BRAF | P15056 | 1/20 | 0.37 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL1572648 | 0.92 | HCRTR1 (0.46) | HCRTR1HCRTR2BACE1 | |
| SCHEMBL1572644 | 0.92 | HCRTR1 (0.46) | HCRTR1HCRTR2BACE1 | |
| SCHEMBL13254749 | 0.88 | HCRTR1 (0.50) | HCRTR1HCRTR2 | |
| SCHEMBL3250335 | 0.87 | HCRTR1 (0.46) | HCRTR1HCRTR2 | |
| SCHEMBL3252470 | 0.86 | HCRTR1 (0.50) | HCRTR1HCRTR2 | |
| SCHEMBL3248850 | 0.86 | HCRTR1 (0.50) | HCRTR1HCRTR2 | |
| SCHEMBL13254771 | 0.86 | HCRTR1 (0.49) | HCRTR1HCRTR2 | |
| SCHEMBL13254759 | 0.84 | HCRTR1 (0.49) | HCRTR1HCRTR2 | |
| SCHEMBL3247804 | 0.83 | HCRTR1 (0.43) | HCRTR1HCRTR2 | |
| SCHEMBL3245436 | 0.82 | HCRTR1 (0.46) | HCRTR1HCRTR2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 6 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-8288429-B2 | 2-aza-bicyclo[3.3.0]octane derivatives | ACTELION PHARMACEUTICALS LTD. (CH) | 2012-10-16 | — | — | US | claimed |
| EP-2183246-A2 | 2-AZA-BICYCLO-[3.3.0]-OCTANE DERIVATIVES | Actelion Pharmaceuticals Ltd. (CH) | 2010-05-12 | — | — | EP | claimed |
| WO-2009016564-A2 | 2-AZA-BICYCLO[3.3.0]OCTANE DERIVATIVES | ACTELION PHARMACEUTICALS LTD (CH) | 2009-02-05 | — | — | WO | claimed |
| US-8288429-B2 | 2-aza-bicyclo[3.3.0]octane derivatives | ACTELION PHARMACEUTICALS LTD. (CH) | 2012-10-16 | — | — | US | disclosed |
| EP-2183246-A2 | 2-AZA-BICYCLO-[3.3.0]-OCTANE DERIVATIVES | Actelion Pharmaceuticals Ltd. (CH) | 2010-05-12 | — | — | EP | disclosed |
| WO-2009016564-A2 | 2-AZA-BICYCLO[3.3.0]OCTANE DERIVATIVES | ACTELION PHARMACEUTICALS LTD (CH) | 2009-02-05 | — | — | WO | disclosed |