Predicted protein targets (top 13)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | CDK2 | P24941 | 19/20 | 0.51 |
| ▸ | CCNA2 | P20248 | 18/20 | 0.51 |
| ▸ | CCNA1 | P78396 | 18/20 | 0.51 |
| ▸ | ELOVL1 | Q9BW60 | 1/20 | 0.44 |
| ▸ | CCNE1 | P24864 | 2/20 | 0.44 |
| ▸ | CDK5 | Q00535 | 2/20 | 0.44 |
| ▸ | CDK5R1 | Q15078 | 2/20 | 0.44 |
| ▸ | CCNB2 | O95067 | 1/20 | 0.44 |
| ▸ | CCNE2 | O96020 | 1/20 | 0.44 |
| ▸ | CDK1 | P06493 | 1/20 | 0.44 |
| ▸ | CCNB1 | P14635 | 1/20 | 0.44 |
| ▸ | CCNB3 | Q8WWL7 | 1/20 | 0.44 |
| ▸ | CDK9 | P50750 | 1/20 | 0.43 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL3254151 | 0.84 | CDK2 (0.45) | CDK2CCNA2CCNA1CCNE1CDK5 | |
| SCHEMBL3256718 | 0.83 | CCNA2 (0.49) | CDK2CCNA2CCNA1 | |
| SCHEMBL3134092 | 0.78 | CDK2 (0.54) | CDK2CCNE1 | |
| SCHEMBL3134085 | 0.78 | CDK2 (0.54) | CDK2CCNE1 | |
| SCHEMBL3127495 | 0.77 | CDK2 (0.51) | CDK2CCNA2CCNA1CCNE1 | |
| SCHEMBL3127501 | 0.77 | CDK2 (0.51) | CDK2CCNA2CCNA1CCNE1 | |
| SCHEMBL3256672 | 0.74 | CDK2 (0.44) | CDK2CCNA2CCNA1CCNE1 | |
| SCHEMBL3124567 | 0.74 | CDK2 (0.49) | CDK2CCNE1 | |
| SCHEMBL3124572 | 0.74 | CDK2 (0.49) | CDK2CCNE1 | |
| SCHEMBL3136929 | 0.74 | CDK2 (0.48) | CDK2CCNE1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1689721-B1 | AMINOPYRAZOLE DERIVATIVES AS GSK-3 INHIBITORS | PFIZER PROD INC (US) | 2010-07-14 | — | — | EP | claimed |