Predicted protein targets (top 19)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | JAK3 | P52333 | 4/20 | 0.56 |
| ▸ | HRH4 | Q9H3N8 | 4/20 | 0.46 |
| ▸ | DRD2 | P14416 | 3/20 | 0.36 |
| ▸ | DRD4 | P21917 | 3/20 | 0.36 |
| ▸ | DRD3 | P35462 | 3/20 | 0.36 |
| ▸ | MEN1 | O00255 | 1/20 | 0.36 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.36 |
| ▸ | JAK2 | O60674 | 1/20 | 0.35 |
| ▸ | JAK1 | P23458 | 1/20 | 0.35 |
| ▸ | LCK | P06239 | 1/20 | 0.35 |
| ▸ | ALDH1A1 | P00352 | 2/20 | 0.35 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.35 |
| ▸ | LMNA | P02545 | 1/20 | 0.35 |
| ▸ | MAPT | P10636 | 1/20 | 0.35 |
| ▸ | HPGD | P15428 | 1/20 | 0.35 |
| ▸ | CYP2D6 | P10635 | 1/20 | 0.35 |
| ▸ | HRH3 | Q9Y5N1 | 1/20 | 0.35 |
| ▸ | GAA | P10253 | 1/20 | 0.34 |
| ▸ | L3MBTL1 | Q9Y468 | 1/20 | 0.34 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL323377 | 0.91 | JAK3 (0.65) | JAK3HRH4JAK2JAK1LCK | |
| SCHEMBL322735 | 0.90 | HRH4 (0.49) | JAK3HRH4DRD2DRD4DRD3 | |
| SCHEMBL322833 | 0.79 | JAK3 (0.45) | JAK3JAK2LCK | |
| SCHEMBL318828 | 0.78 | JAK3 (0.86) | JAK3JAK2JAK1LCK | |
| SCHEMBL322327 | 0.77 | JAK3 (0.63) | JAK3JAK2JAK1CYP2D6 | |
| SCHEMBL1048640 | 0.74 | JAK3 (0.83) | JAK3JAK2JAK1LCKCYP2D6 | |
| SCHEMBL10206821 | 0.72 | JAK3 (1.00) | JAK3JAK2LCK | |
| SCHEMBL322506 | 0.72 | JAK3 (0.51) | JAK3JAK2JAK1LCK | |
| SCHEMBL323558 | 0.70 | NTRK1 (0.42) | JAK3MEN1KMT2AJAK2JAK1 | |
| SCHEMBL21538581 | 0.70 | JAK3 (0.90) | JAK3JAK2JAK1LCKCYP2D6 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-2590981-A1 | NOVEL HOMOPIPERAZINE DERIVATIVES AS PROTEIN TYROSINE KINASE INHIBITORS AND PHARMACEUTICAL USE THEREOF | Leo Pharma A/S (DK) | 2013-05-15 | — | — | EP | disclosed |
| WO-2012003829-A1 | NOVEL HOMOPIPERAZINE DERIVATIVES AS PROTEIN TYROSINE KINASE INHIBITORS AND PHARMACEUTICAL USE THEREOF | LEO PHARMA A/S (DK) | 2012-01-12 | — | — | WO | disclosed |