⚠ Novel chemotype — no close known analogue (best Tanimoto < 0.3). Unexplored chemical space relative to ChEMBL.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL3253096 | 1.00 | — | — | |
| SCHEMBL29980156 | 0.75 | TSHR (0.32) | — | |
| SCHEMBL13195748 | 0.75 | — | — | |
| SCHEMBL29176466 | 0.67 | — | — | |
| SCHEMBL9978571 | 0.67 | — | — | |
| SCHEMBL2123459 | 0.65 | — | — | |
| SCHEMBL3053425 | 0.65 | — | — | |
| SCHEMBL29138738 | 0.65 | — | — | |
| SCHEMBL6738278 | 0.65 | — | — | |
| SCHEMBL176693 | 0.63 | — | — |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 19 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| CN-116425659-B | Method for synthesizing peramivir | 浙江康聚药业有限公司 | 2023-11-03 | — | — | CN | claimed |
| CN-116425659-A | Method for synthesizing peramivir | 浙江康聚药业有限公司 | 2023-07-14 | — | — | CN | claimed |
| CN-118359556-A | Preparation method of peramivir trihydrate key intermediate | 泓博智源(开原)药业有限公司 | 2024-07-19 | — | — | CN | disclosed |
| CN-118359556-A | Preparation method of peramivir trihydrate key intermediate | 泓博智源(开原)药业有限公司 | 2024-07-19 | — | — | CN | disclosed |
| CN-114835654-B | Preparation method of peramivir key intermediate | 重庆恩联生物科技有限公司 | 2024-02-27 | — | — | CN | disclosed |
| CN-116425659-B | Method for synthesizing peramivir | 浙江康聚药业有限公司 | 2023-11-03 | — | — | CN | disclosed |
| CN-116425659-A | Method for synthesizing peramivir | 浙江康聚药业有限公司 | 2023-07-14 | — | — | CN | disclosed |
| EP-2186795-B1 | (1S, 2S, 3S, 4R)-3-Ý(1S)-1-ACETYLAMINO-2-ETHYL-BUTYL¨-4-GUANIDINO-2- HYDROXYL-CYCLOPENTYL-1-CARBOXYLIC ACID HYDRATES AND PHARMACEUTICAL USES THEREOF | HUNAN NANXIN PHARMACEUTICAL CO LTD (CN) | 2019-09-25 | — | — | EP | disclosed |
| US-9518008-B2 | (1S,2S,3S,4R)-3-[(1S)-1-acetylamino-2-ethyl-butyl]-4-uanidino-2-hydroxyl-cyclopentyl-1-carboxylic acid hydrates pharmaceutical uses thereof | INSTITUTE OF PHARMACOLOGY AND TOXICOLOGY ACADEMY OF MILITARY MEDICAL SCIENCES P.L.A., CHINA (CN) | 2016-12-13 | — | — | US | disclosed |
| US-9272992-B2 | (1S,2S,3S,4R)-3-[(1S)-1-acetylamino-2-ethyl-butyl]-4-guanidino-2-hydroxy-cyclopentyl-l-carboxylic acid hydrates pharmaceutical uses thereof | INSTITUTE OF PHARMACOLOGY AND TOXICOLOGY ACADEMY OF MILITARY MEDICAL SCIENCES P.L.A., CHINA (CN) | 2016-03-01 | — | — | US | disclosed |
| US-20150133556-A1 | (1S,2S,3S,4R)-3-[(1S)-1-ACETYLAMINO-2-ETHYL-BUTYL]-4-UANIDINO-2-HYDROXYL-CYCLOPENTYL-1-CARBOXYLIC ACID HYDRATES PHARMACEUTICAL USES THEREOF | INSTITUTE OF PHARMACOLOGY AND TOXICOLOGY ACADEMY OF MILITARY MEDICAL SCIENCES P.L.A., CHINA (CN) | 2015-05-14 | — | — | US | disclosed |
| US-20130331604-A1 | (1S,2S,3S,4R)-3-[(1S)-1-acetylamino-2-ethyl-butyl)-4-guanidino-2-hydroxy-cyclopentyl-1-carboxylic acid hydrates pharmaceutical uses thereof | INSTITUTE OF PHARMACOLOGY AND TOXICOLOGY ACADEMY OF MILITARY MEDICAL SCIENCES P.L.A., CHINA (CN) | 2013-12-12 | — | — | US | disclosed |
| WO-2012145932-A1 | A NOVEL PROCESS FOR THE PREPARATION OF PERAMIVIR AND INTERMEDIATES THEREOF | PHARMARESOURCES (SHANGHAI) CO., LTD. (CN) | 2012-11-01 | — | — | WO | disclosed |
| US-20110065795-A1 | (1S,2S,3S,4R)-3-[(1S)-1-ACETYLAMINO-2-ETHYL-BUTYL]-4-UANIDINO-2-HYDROXYL-CYCLOPENTYL-1-CARBOXYLIC ACID HYDRATES PHARMACEUTICAL USES THEREOF | INSTITUTE OF PHARMACOLOGY AND TOXICOLOGY ACADEMY OF MILITARY MEDICAL SCIENCES P.L.A. CHINA (CN) | 2011-03-17 | — | — | US | disclosed |
| EP-2186795-A1 | (1S, 2S, 3S, 4R)-3-Ý(1S)-1-ACETYLAMINO-2-ETHYL-BUTYL¨-4-GUANIDINO-2- HYDROXYL-CYCLOPENTYL-1-CARBOXYLIC ACID HYDRATES AND PHARMACEUTICAL USES THEREOF | Institute Of Pharmacology And Toxicology Academy Of Military Medical Sciences P.L.A. China (CN) | 2010-05-19 | — | — | EP | disclosed |
| US-6576786-B2 | Reacting an n-protected carboxy-amine-cyclopentane derivative with a nitrile oxide followed by salt formation, desalting, decyclization, deprotecting and amidation | BIOCRYST PHARMACEUTICALS INC. | 2003-06-10 | — | — | US | disclosed |
| EP-1214294-A1 | PROCESS FOR PREPARING SUBSTITUTED CYCLOPENTANE DERIVATIVES AND NOVEL CRYSTALLINE STRUCTURES THEREOF | BIOCRYST PHARMACEUTICALS, INC. (US) | 2002-06-19 | — | — | EP | disclosed |
| US-20020061930-A1 | Process for preparing substituted cyclopentane derivatives and novel crystalline structures thereof | BIOCRYST PHARMACEUTICALS, INC. | 2002-05-23 | — | — | US | disclosed |
| WO-2001000571-A1 | PROCESS FOR PREPARING SUBSTITUTED CYCLOPENTANE DERIVATIVES AND NOVEL CRYSTALLINE STRUCTURES THEREOF | ORTHO-MCNEIL PHARMACEUTICAL, INC. (US) | 2001-01-04 | — | — | WO | disclosed |