Predicted protein targets (top 19)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | ALDH1A1 | P00352 | 4/20 | 0.44 |
| ▸ | PRMT5 | O14744 | 4/20 | 0.38 |
| ▸ | WDR77 | Q9BQA1 | 4/20 | 0.38 |
| ▸ | RXFP1 | Q9HBX9 | 1/20 | 0.37 |
| ▸ | P2RX1 | P51575 | 1/20 | 0.36 |
| ▸ | P2RX3 | P56373 | 1/20 | 0.36 |
| ▸ | P2RX4 | Q99571 | 1/20 | 0.36 |
| ▸ | PI4KA | P42356 | 1/20 | 0.36 |
| ▸ | PI4K2B | Q8TCG2 | 1/20 | 0.36 |
| ▸ | PI4K2A | Q9BTU6 | 1/20 | 0.36 |
| ▸ | PI4KB | Q9UBF8 | 1/20 | 0.36 |
| ▸ | CYP3A4 | P08684 | 1/20 | 0.35 |
| ▸ | LMNA | P02545 | 1/20 | 0.35 |
| ▸ | POLB | P06746 | 1/20 | 0.35 |
| ▸ | GAA | P10253 | 1/20 | 0.35 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.35 |
| ▸ | NPSR1 | Q6W5P4 | 1/20 | 0.35 |
| ▸ | HTT | P42858 | 1/20 | 0.34 |
| ▸ | ADK | P55263 | 1/20 | 0.33 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL314866 | 0.86 | PRMT5 (0.39) | PRMT5WDR77RXFP1P2RX1P2RX3 | |
| SCHEMBL324410 | 0.85 | PI4KA (0.43) | PRMT5WDR77RXFP1P2RX1P2RX3 | |
| SCHEMBL314858 | 0.84 | RXFP1 (0.41) | PRMT5WDR77RXFP1P2RX1P2RX3 | |
| SCHEMBL18009882 | 0.81 | PRMT5 (0.42) | PRMT5WDR77RXFP1P2RX1P2RX3 | |
| SCHEMBL24687531 | 0.80 | RXFP1 (0.41) | PRMT5WDR77RXFP1P2RX1P2RX3 | |
| SCHEMBL18572224 | 0.80 | PRMT5 (0.52) | PRMT5WDR77RXFP1P2RX1P2RX3 | |
| SCHEMBL10131056 | 0.80 | RXFP1 (0.41) | PRMT5WDR77RXFP1P2RX1P2RX3 | |
| SCHEMBL18535190 | 0.80 | RXFP1 (0.41) | PRMT5WDR77RXFP1P2RX1P2RX3 | |
| SCHEMBL18009694 | 0.80 | RXFP1 (0.41) | PRMT5WDR77RXFP1P2RX1P2RX3 | |
| SCHEMBL18009779 | 0.78 | RXFP1 (0.40) | PRMT5WDR77RXFP1P2RX1P2RX3 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 5 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-3133080-B1 | NOVEL CYTOSTATIC 7-DEAZAPURINE NUCLEOSIDES | INST OF ORGANIC CHEMISTRY AND BIOCHEMISTRY OF THE ACADEMY OF SCIENCES OF THE CZECH REPUBLIC (CZ) | 2018-08-01 | — | — | EP | disclosed |
| EP-3133080-A1 | NOVEL CYTOSTATIC 7-DEAZAPURINE NUCLEOSIDES | INSTITUTE OF ORGANIC CHEMISTRY AND BIOCHEMISTRY OF THE ACADEMY OF SCIENCES OF THE CZECH REPUBLIC (CZ) | 2017-02-22 | — | — | EP | disclosed |
| EP-2231689-B1 | NOVEL CYTOSTATIC 7-DEAZAPURINE NUCLEOSIDES | ACAD OF SCIENCE CZECH REPUBLIC (CZ) | 2016-07-20 | — | — | EP | disclosed |
| US-8093226-B2 | Cytostatic 7-deazapurine nucleosides | INSTITUTE OF ORGANIC CHEMISTRY AND BIOCHEMISTRY OF THE ASCR, V.V.I. (CZ) | 2012-01-10 | — | — | US | disclosed |
| US-20090203637-A1 | NOVEL CYTOSTATIC 7-DEAZAPURINE NUCLEOSIDES | INSTITUTE OF ORGANIC CHEMISTRY AND BIOCHEMISTRY OF THE ASCR, V.V.I. | 2009-08-13 | — | — | US | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20090203637-A1 | NOVEL CYTOSTATIC 7-DEAZAPURINE NUCLEOSIDES | TYMP, TYMS, DPYD | ALDH1A1 470/4885PRMT5 245/4885WDR77 172/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.