Predicted protein targets (top 7)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | DPP4 | P27487 | 20/20 | 0.64 |
| ▸ | DPP8 | Q6V1X1 | 11/20 | 0.64 |
| ▸ | DPP9 | Q86TI2 | 5/20 | 0.64 |
| ▸ | DPP7 | Q9UHL4 | 5/20 | 0.64 |
| ▸ | ACE | P12821 | 1/20 | 0.64 |
| ▸ | HTR2A | P28223 | 1/20 | 0.64 |
| ▸ | FAP | Q12884 | 1/20 | 0.64 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL3254233 | 1.00 | DPP4 (0.64) | DPP4DPP8DPP9DPP7ACE | |
| SCHEMBL28030532 | 0.89 | DPP4 (0.60) | DPP4DPP8DPP9DPP7ACE | |
| SCHEMBL14550105 | 0.85 | DPP4 (0.76) | DPP4DPP8DPP9DPP7ACE | |
| SCHEMBL3697380 | 0.81 | DPP4 (0.65) | DPP4DPP8DPP9DPP7ACE | |
| SCHEMBL15206677 | 0.81 | DPP4 (0.65) | DPP4DPP8DPP9DPP7ACE | |
| SCHEMBL14634817 | 0.79 | DPP4 (0.68) | DPP4DPP8DPP9DPP7ACE | |
| SCHEMBL2477394 | 0.79 | DPP4 (0.68) | DPP4DPP8DPP9DPP7ACE | |
| Hydrochloric Acid SCHEMBL1842315 | 0.78 | DPP4 (0.64) | DPP4DPP8DPP9DPP7ACE | |
| Hydrochloric Acid SCHEMBL1842319 | 0.78 | DPP4 (0.64) | DPP4DPP8DPP9DPP7ACE | |
| SCHEMBL1289271 | 0.78 | DPP4 (0.56) | DPP4DPP8DPP9DPP7ACE |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1911756-B9 | Substituted pyridinyl and pyrimidinyl derivatives as modulators of metabolism and the treatment of disorders related thereto | ARENA PHARM INC (US) | 2010-05-26 | — | — | EP | claimed |
| EP-1911756-B1 | Substituted pyridinyl and pyrimidinyl derivatives as modulators of metabolism and the treatment of disorders related thereto | ARENA PHARM INC (US) | 2009-10-21 | — | — | EP | claimed |