Predicted protein targets (top 3)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | PIM1 | P11309 | 1/20 | 0.32 |
| ▸ | PIM3 | Q86V86 | 1/20 | 0.32 |
| ▸ | PIM2 | Q9P1W9 | 1/20 | 0.32 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL1910734 | 0.87 | PIM1 (0.43) | PIM1PIM3PIM2 | |
| SCHEMBL325465 | 0.87 | PIM1 (0.43) | PIM1PIM3PIM2 | |
| SCHEMBL319196 | 0.78 | PIM1 (0.33) | PIM1PIM3PIM2 | |
| SCHEMBL319197 | 0.78 | PIM1 (0.33) | PIM1PIM3PIM2 | |
| SCHEMBL319187 | 0.78 | PIM1 (0.33) | PIM1PIM3PIM2 | |
| SCHEMBL319188 | 0.78 | PIM1 (0.33) | PIM1PIM3PIM2 | |
| SCHEMBL319186 | 0.78 | PIM1 (0.33) | PIM1PIM3PIM2 | |
| SCHEMBL319084 | 0.76 | PIM1 (0.46) | PIM1PIM3PIM2 | |
| SCHEMBL319085 | 0.76 | PIM1 (0.46) | PIM1PIM3PIM2 | |
| SCHEMBL10278541 | 0.70 | MEN1 (0.30) | — |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-2590968-A1 | CYCLIC ETHER COMPOUNDS USEFUL AS KINASE INHIBITORS | Novartis AG (CH) | 2013-05-15 | — | — | EP | disclosed |
| WO-2012004217-A1 | CYCLIC ETHER COMPOUNDS USEFUL AS KINASE INHIBITORS | NOVARTIS AG (CH) | 2012-01-12 | — | — | WO | disclosed |