Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | PPARA | Q07869 | 1/20 | 0.48 |
| ▸ | ATM | Q13315 | 2/20 | 0.44 |
| ▸ | HDAC1 | Q13547 | 4/20 | 0.42 |
| ▸ | HDAC2 | Q92769 | 3/20 | 0.42 |
| ▸ | HDAC8 | Q9BY41 | 3/20 | 0.42 |
| ▸ | TSHR | P16473 | 2/20 | 0.42 |
| ▸ | MEN1 | O00255 | 1/20 | 0.42 |
| ▸ | LMNA | P02545 | 1/20 | 0.42 |
| ▸ | HTT | P42858 | 1/20 | 0.42 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.42 |
| ▸ | SPHK1 | Q9NYA1 | 1/20 | 0.41 |
| ▸ | NPSR1 | Q6W5P4 | 1/20 | 0.41 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.40 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.40 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.40 |
| ▸ | S1PR1 | P21453 | 2/20 | 0.39 |
| ▸ | S1PR3 | Q99500 | 2/20 | 0.39 |
| ▸ | S1PR2 | O95136 | 1/20 | 0.39 |
| ▸ | LPAR2 | Q9HBW0 | 1/20 | 0.39 |
| ▸ | TDP1 | Q9NUW8 | 1/20 | 0.38 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL1325131 | 0.78 | SPHK1 (0.54) | PPARAATMHDAC1HDAC2HDAC8 | |
| SCHEMBL97644 | 0.75 | PPARA (0.50) | PPARAATMHDAC1HDAC2HDAC8 | |
| SCHEMBL97645 | 0.75 | PPARA (0.50) | PPARAATMHDAC1HDAC2HDAC8 | |
| SCHEMBL95287 | 0.73 | PPARA (0.47) | PPARAATMHDAC1HDAC2HDAC8 | |
| SCHEMBL95288 | 0.72 | NOTUM (0.50) | PPARAATMHDAC1HDAC2HDAC8 | |
| SCHEMBL1325065 | 0.71 | SPHK1 (0.55) | PPARAATMHDAC1HDAC2HDAC8 | |
| SCHEMBL3265321 | 0.71 | SPHK1 (0.55) | PPARAATMHDAC1HDAC2HDAC8 | |
| SCHEMBL1325717 | 0.71 | SPHK1 (0.55) | PPARAATMHDAC1HDAC2HDAC8 | |
| SCHEMBL12380049 | 0.70 | NPC1 (0.69) | PPARATSHRMEN1HTTKMT2A | |
| SCHEMBL12121023 | 0.69 | SPHK1 (0.54) | PPARAATMHDAC1HDAC2HDAC8 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2010033701-A2 | INHIBITORS OF SPHINGOSINE KINASE 1 | GENZYME CORPORATION (US) | 2010-03-25 | — | — | WO | disclosed |