Predicted protein targets (top 9)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | LCK | P06239 | 20/20 | 1.00 |
| ▸ | KIT | P10721 | 17/20 | 1.00 |
| ▸ | SRC | P12931 | 16/20 | 1.00 |
| ▸ | KDR | P35968 | 10/20 | 1.00 |
| ▸ | ABL1 | P00519 | 1/20 | 0.82 |
| ▸ | PDGFRA | P16234 | 1/20 | 0.82 |
| ▸ | JAK3 | P52333 | 3/20 | 0.46 |
| ▸ | MAPK14 | Q16539 | 3/20 | 0.46 |
| ▸ | TEK | Q02763 | 2/20 | 0.46 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL3250868 | 0.92 | LCK (1.00) | LCKKITSRCKDRABL1 | |
| SCHEMBL3248091 | 0.90 | LCK (1.00) | LCKKITSRCKDRABL1 | |
| SCHEMBL3254427 | 0.89 | LCK (0.81) | LCKKITSRCKDRABL1 | |
| SCHEMBL3253340 | 0.88 | LCK (0.78) | LCKKITSRCKDRABL1 | |
| SCHEMBL3249706 | 0.87 | LCK (1.00) | LCKKITSRCKDRABL1 | |
| SCHEMBL3257003 | 0.87 | LCK (0.80) | LCKKITSRCKDRABL1 | |
| SCHEMBL3250978 | 0.87 | LCK (1.00) | LCKKITSRCKDRABL1 | |
| SCHEMBL3249849 | 0.86 | LCK (0.82) | LCKKITSRCKDRABL1 | |
| SCHEMBL3249502 | 0.86 | LCK (0.82) | LCKKITSRCKDRABL1 | |
| SCHEMBL3252054 | 0.86 | LCK (0.81) | LCKKITSRCKDRABL1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-7700607-B2 | Substituted pyridone compounds and methods of use | AMGEN INC. | 2010-04-20 | — | — | US | claimed |
| EP-2079724-B1 | SUBSTITUTED PYRIDONE COMPOUNDS AND METHODS OF USE | AMGEN INC (US) | 2010-05-26 | — | — | EP | disclosed |